Blood pressure-lowering and vascular modulator effects of Acorus calamus extract are mediated through multiple pathways

Abdul Jabbar Shah, Anwarul Hassan Gilani

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

This investigation was aimed to provide a pharmacologic basis to the medicinal use of Acorus calamus in cardiovascular disorders. In normotensive anesthetized rats, crude extract of Acorus calamus and its ethylacetate and nHexane fractions caused a fall in mean arterial pressure. In rabbit aorta rings, crude extract was more potent against high K (80 mM), ethylacetate against phenylephrine (1 μM), whereas nHexane fraction was equipotent against both precontractions. Crude extract exhibited a vasoconstrictor effect on baseline. Pretreatment of aortic rings with crude extract and its fractions shifted Ca concentration-response curves to the right, similar to verapamil. Crude extract and ethylacetate fraction suppressed phenylephrine peak formation in Ca-free medium. In rat aorta preparations, crude extract exhibited endothelium-independent relaxation with a vasodilatory effect against high K. nHexane fraction caused an endothelium-dependent Nω-nitro-l-arginine methyl ester-sensitive vasorelaxant along with ryanodine-sensitive vasoconstrictor effect on baseline tension and partially inhibited high K, although ethylacetate fraction caused an endothelium-independent relaxant and endothelium-dependent vasoconstrictor effect. These data indicate that crude extract possesses a combination of effects, relaxant effects mediated possibly through Ca antagonism in addition to a nitric oxide pathway, although the associated vasoconstrictor effects may be meant by nature to offset excessive vasodilatation, thus providing a pharmacologic rationale to its cardiovascular medi-cinal uses.

Original languageEnglish
Pages (from-to)38-46
Number of pages9
JournalJournal of Cardiovascular Pharmacology
Volume54
Issue number1
DOIs
Publication statusPublished - Jul 2009
Externally publishedYes

Keywords

  • Acorus calamus extract
  • Antihypertensive
  • Ca antagonist
  • NO-mediated
  • Vasomodulator

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