TY - JOUR
T1 - Body composition at birth and its relationship with neonatal anthropometric ratios
T2 - The newborn body composition study of the INTERGROWTH-21 st project
AU - Villar, José
AU - Puglia, Fabien A.
AU - Fenton, Tanis R.
AU - Cheikh Ismail, Leila
AU - Staines-Urias, Eleonora
AU - Giuliani, Francesca
AU - Ohuma, Eric O.
AU - Victora, Cesar G.
AU - Sullivan, Peter
AU - Barros, Fernando C.
AU - Lambert, Ann
AU - Papageorghiou, Aris T.
AU - Ochieng, Roseline
AU - Jaffer, Yasmin A.
AU - Altman, Douglas G.
AU - Noble, Alison J.
AU - Gravett, Michael G.
AU - Purwar, Manorama
AU - Pang, Ruyan
AU - Uauy, Ricardo
AU - Kennedy, Stephen H.
AU - Bhutta, Zulfiqar A.
N1 - Publisher Copyright:
© 2017 International Pediatric Research Foundation, Inc.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - BackgroundWe aimed to describe newborn body composition and identify which anthropometric ratio (weight/length; BMI; or ponderal index, PI) best predicts fat mass (FM) and fat-free mass (FFM).MethodsAir-displacement plethysmography (PEA POD) was used to estimate FM, FFM, and body fat percentage (BF%). Associations between FFM, FM, and BF% and weight/length, BMI, and PI were evaluated in 1,019 newborns using multivariate regression analysis. Charts for FM, FFM, and BF% were generated using a prescriptive subsample (n=247). Standards for the best-predicting anthropometric ratio were calculated utilizing the same population used for the INTERGROWTH-21 st Newborn Size Standards (n=20,479).ResultsFFM and FM increased consistently during late pregnancy. Differential FM, BF%, and FFM patterns were observed for those born preterm (34 +0 -36 +6 weeks' gestation) and with impaired intrauterine growth. Weight/length by gestational age (GA) was a better predictor of FFM and FM (adjusted R 2 =0.92 and 0.71, respectively) than BMI or PI, independent of sex, GA, and timing of measurement. Results were almost identical when only preterm newborns were studied. We present sex-specific centiles for weight/length ratio for GA.ConclusionsWeight/length best predicts newborn FFM and FM. There are differential FM, FFM, and BF% patterns by sex, GA, and size at birth.
AB - BackgroundWe aimed to describe newborn body composition and identify which anthropometric ratio (weight/length; BMI; or ponderal index, PI) best predicts fat mass (FM) and fat-free mass (FFM).MethodsAir-displacement plethysmography (PEA POD) was used to estimate FM, FFM, and body fat percentage (BF%). Associations between FFM, FM, and BF% and weight/length, BMI, and PI were evaluated in 1,019 newborns using multivariate regression analysis. Charts for FM, FFM, and BF% were generated using a prescriptive subsample (n=247). Standards for the best-predicting anthropometric ratio were calculated utilizing the same population used for the INTERGROWTH-21 st Newborn Size Standards (n=20,479).ResultsFFM and FM increased consistently during late pregnancy. Differential FM, BF%, and FFM patterns were observed for those born preterm (34 +0 -36 +6 weeks' gestation) and with impaired intrauterine growth. Weight/length by gestational age (GA) was a better predictor of FFM and FM (adjusted R 2 =0.92 and 0.71, respectively) than BMI or PI, independent of sex, GA, and timing of measurement. Results were almost identical when only preterm newborns were studied. We present sex-specific centiles for weight/length ratio for GA.ConclusionsWeight/length best predicts newborn FFM and FM. There are differential FM, FFM, and BF% patterns by sex, GA, and size at birth.
UR - https://www.scopus.com/pages/publications/85027362521
U2 - 10.1038/pr.2017.52
DO - 10.1038/pr.2017.52
M3 - Article
C2 - 28445454
AN - SCOPUS:85027362521
SN - 0031-3998
VL - 82
SP - 305
EP - 316
JO - Pediatric Research
JF - Pediatric Research
IS - 2
ER -