@article{0b4730ee66784269b7290141a61e2fd5,
title = "Body composition reference charts for infants from birth to 24 months: Multicenter Infant Body Composition Reference Study",
abstract = "Background: Body composition assessment in the first 2 y of life provides important insights into child nutrition and health. The application and interpretation of body composition data in infants and young children have been challenged by a lack of global reference data. Objectives: We aimed to develop body composition reference charts of infants aged 0–6 mo based on air displacement plethysmography (ADP) and those aged 3–24 mo based on total body water (TBW) by deuterium dilution (DD). Methods: Body composition was assessed by ADP in infants aged 0–6 mo from Australia, India, and South Africa. TBW using DD was assessed for infants aged 3–24 mo from Brazil, Pakistan, South Africa, and Sri Lanka. Reference charts and centiles were constructed for body composition using the lambda–mu–sigma method. Results: Sex-specific reference charts were produced for FM index (FMI), FFM index (FFMI), and percent FM (%FM) for infants aged 0–6 mo (n = 470 infants; 1899 observations) and 3–24 mo (n = 1026 infants; 3690 observations). When compared with other available references, there were observable differences but similar patterns in the trajectories of FMI, FFMI, and %FM. Conclusions: These reference charts will strengthen the interpretation and understanding of body composition in infants across the first 24 mo of life.",
keywords = "air displacement plethysmography, body composition, deuterium dilution, fat mass index, fat-free mass index, infants, reference charts",
author = "{Multicenter Infant Body Composition Reference Study (MIBCRS)} and Murphy-Alford, {Alexia J.} and William Johnson and Nyati, {Lukhanyo H.} and Santos, {Ina S.} and Hills, {Andrew P.} and Shabina Ariff and Wickramasinghe, {V. Pujitha} and Rebecca Kuriyan and Lucas, {M. Nishani} and Costa, {Caroline S.} and Christine Slater and Tanvir Ahmad and Byrne, {Nuala M.} and Divya, {Priscilla J.} and Kurpad, {Anura V.} and {Cheikh Ismail}, {Leila I.} and Loechl, {Cornelia U.} and Norris, {Shane A.}",
note = "Funding Information: This work was supported by the International Atomic Energy Agency ( IAEA; CRP E43028 ). IAEA participated in the design, management, analysis, interpretation, preparation, review, and approval of the manuscript. This work was supported, in whole or in part, by the Bill & Melinda Gates Foundation [ OPP1143641 ]. Under the grant conditions of the Foundation, a Creative Commons Attribution 4.0 Generic License has already been assigned to the author accepted manuscript version that might arise from this submission. The Bill & Melinda Gates Foundation did not participate in the design, management, analysis, interpretation, or preparation of the manuscript. WJ acknowledges support from the National Institute for Health Research (NIHR), Leicester Biomedical Research Centre, which is a partnership between University Hospitals of Leicester NHS Trust, Loughborough University, and the University of Leicester. Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
month = jun,
doi = "10.1016/j.ajcnut.2023.02.012",
language = "English",
volume = "117",
pages = "1262--1269",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "6",
}