Bombesin-induced behavioural changes: Antagonism by neuroleptics

Z. Merali, S. Johnston, S. Zalcman

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

Adult male Sprague-Dawley rats were administered bombesin (BN) intracerebroventricularly (ICV), at a dose of 0.001, 0.01, 0.1, or 1.0 μg, and the behavioural effects monitored longitudinally across time for up to 24 hr. Administration of BN significantly increased the locomotor, rearing and grooming activity at all doses. The time-course of behavioural activation was dose-related (lasting up to 2.5 hr). There was no significant difference in the behavioural response of rats receiving the BN doses in an ascending or descending order. To test the effects of dopamine receptor blockade on the BN-induced behavioural changes, groups of animals were treated with fluphenazine or haloperidol (0.1 to 2.5 mg/kg, IP) 30 min prior to BN (1 μg, ICV) administration. The results revealed that the neuroleptics could effectively antagonize the BN-induced activation of locomotor, rearing and grooming activity. These data are concordant with the view that centrally administered BN stimulates spontaneous exploratory and grooming behaviours in rats, in a time- and dose-related manner. Furthermore, since neuroleptics block these effects, it remains possible that the BN-induced behavioural changes may be mediated, at least in part, through the dopaminergic system(s).

Original languageEnglish
Pages (from-to)693-697
Number of pages5
JournalPeptides
Volume4
Issue number5
DOIs
Publication statusPublished - 1983
Externally publishedYes

Keywords

  • Behaviour
  • Behavioural antagonism by neuroleptics
  • Bombesin
  • Fluphenazine
  • Haloperidol
  • Rats

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