Bombesin-induced HPA and sympathetic activation requires CRH receptors

Pam Kent, Tania Bédard, Samir Khan, Hymie Anisman, Zul Merali

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with αh-CRF (10 μg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
Issue number1
Publication statusPublished - 2001
Externally publishedYes


  • ACTH
  • Corticosterone
  • Epinephrine
  • Gastrin-releasing peptide
  • Glucose
  • Norepinephrine


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