Bombesin-induced HPA and sympathetic activation requires CRH receptors

Pam Kent; Tania Bédard; Samir Khan; Hymie Anisman; Zul Merali

doi:10.1016/S0196-9781(00)00355-7

Bombesin-induced HPA and sympathetic activation requires CRH receptors

Pam Kent, Tania Bédard, Samir Khan, Hymie Anisman, Zul Merali

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with αh-CRF (10 μg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons.

Original language	English
Pages (from-to)	57-65
Number of pages	9
Journal	Peptides
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/S0196-9781(00)00355-7
Publication status	Published - 2001
Externally published	Yes

Keywords

ACTH
Corticosterone
Epinephrine
Gastrin-releasing peptide
Glucose
Norepinephrine

Access to Document

10.1016/S0196-9781(00)00355-7

Cite this

@article{2bc127e248624a77ba3c00967fa471db,

title = "Bombesin-induced HPA and sympathetic activation requires CRH receptors",

abstract = "Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with αh-CRF (10 μg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons.",

keywords = "ACTH, Corticosterone, Epinephrine, Gastrin-releasing peptide, Glucose, Norepinephrine",

author = "Pam Kent and Tania B{\'e}dard and Samir Khan and Hymie Anisman and Zul Merali",

note = "Funding Information: This work was supported by a grant from the Medical Research Council of Canada and an Ontario Graduate Student Scholarship.",

year = "2001",

doi = "10.1016/S0196-9781(00)00355-7",

language = "English",

volume = "22",

pages = "57--65",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "1",

}

TY - JOUR

T1 - Bombesin-induced HPA and sympathetic activation requires CRH receptors

AU - Kent, Pam

AU - Bédard, Tania

AU - Khan, Samir

AU - Anisman, Hymie

AU - Merali, Zul

N1 - Funding Information: This work was supported by a grant from the Medical Research Council of Canada and an Ontario Graduate Student Scholarship.

PY - 2001

Y1 - 2001

N2 - Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with αh-CRF (10 μg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons.

AB - Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system. We then assessed the potential contribution of corticotropin-releasing hormone (CRH) system, in the mediation of these BN effects. Blockade of CRH receptors with αh-CRF (10 μg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels. These findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons.

KW - ACTH

KW - Corticosterone

KW - Epinephrine

KW - Gastrin-releasing peptide

KW - Glucose

KW - Norepinephrine

UR - http://www.scopus.com/inward/record.url?scp=0035134249&partnerID=8YFLogxK

U2 - 10.1016/S0196-9781(00)00355-7

DO - 10.1016/S0196-9781(00)00355-7

M3 - Article

C2 - 11179598

AN - SCOPUS:0035134249

SN - 0196-9781

VL - 22

SP - 57

EP - 65

JO - Peptides

JF - Peptides

IS - 1

ER -

Bombesin-induced HPA and sympathetic activation requires CRH receptors

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this