Bone marrow necrosis - Initial presentation in sickle cell anaemia

Maria Shafiq, Natasha Ali

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objective: Unusual clinical course Background: In sickle cell disease, bone involvement is the commonest clinical presentation in the acute as well as chronic setting presenting as painful vaso-occlusive crisis and avascular necrosis respectively. Other complications include bone marrow necrosis and infarction. Case-Report: We report a case of a 20 year old male who was referred for bone marrow evaluation due to symptoms of fever, weakness and repeated episodes of bone pains. Bone trephine biopsy revealed multiple areas of central necrosis surrounded by fibroblasts. Conclusions: Recognition of necrosis through bone trephine biopsy is important for early institution of therapy.

Original languageEnglish
Pages (from-to)416-418
Number of pages3
JournalAmerican Journal of Case Reports
Publication statusPublished - 16 Oct 2013


  • Bone marrow
  • Necrosis
  • Sickle cell


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