Breast cancer treatment: A phased approach to implementation

Miriam Mutebi, Benjamin O. Anderson, Catherine Duggan, Clement Adebamowo, Gaurav Agarwal, Zipporah Ali, Peter Bird, Jean Marc Bourque, Rebecca DeBoer, Luiz Henrique Gebrim, Riccardo Masetti, Shahla Masood, Manoj Menon, Gertrude Nakigudde, Anne Ng’ang’a, Nixon Niyonzima, Anne F. Rositch, Karla Unger-Saldaña, Cynthia Villarreal-Garza, Allison DvaladzeNagi S. El Saghir, Julie R. Gralow, Alexandru Eniu

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)


Optimal treatment outcomes for breast cancer are dependent on a timely diagnosis followed by an organized, multidisciplinary approach to care. However, in many low- and middle-income countries, effective care management pathways can be difficult to follow because of financial constraints, a lack of resources, an insufficiently trained workforce, and/or poor infrastructure. On the basis of prior work by the Breast Health Global Initiative, this article proposes a phased implementation strategy for developing sustainable approaches to enhancing patient care in limited-resource settings by creating roadmaps that are individualized and adapted to the baseline environment. This strategy proposes that, after a situational analysis, implementation phases begin with bolstering palliative care capacity, especially in settings where a late-stage diagnosis is common. This is followed by strengthening the patient pathway, with consideration given to a dynamic balance between centralization of services into centers of excellence to achieve better quality and decentralization of services to increase patient access. The use of resource checklists ensures that comprehensive therapy or palliative care can be delivered safely and effectively. Episodic or continuous monitoring with established process and quality metrics facilitates ongoing assessment, which should drive continual process improvements. A series of case studies provides a snapshot of country experiences with enhancing patient care, including the implementation of national cancer control plans in Kenya, palliative care in Romania, the introduction of a 1-stop clinic for diagnosis in Brazil, the surgical management of breast cancer in India, and the establishment of a women’s cancer center in Ghana. Cancer 2020;126:2365-2378.

Original languageEnglish
Pages (from-to)2365-2378
Number of pages14
Issue numberS10
Publication statusPublished - 2020


  • Breast cancer
  • Cancer center of excellence
  • Centralized care
  • Decentralized care
  • Dissemination and implementation science
  • Early diagnosis
  • Health disparities
  • Low- and middle-income countries (LMICs)
  • Multidisciplinary evaluation
  • Phased implementation
  • Resource-stratification
  • Supportive and palliative care
  • Treatment
  • Underserved communities


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