Breast diseases: a histopathological analysis of 3279 cases at a tertiary care center in Pakistan.

M. S. Siddiqui, N. Kayani, M. S. Gill, S. Pervez, S. Muzaffar, S. A. Aziz, Z. Setna, M. Israr, S. H. Hasan

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


OBJECTIVE: To know the frequency of breast diseases in Pakistani females. METHODS: A retrospective analysis of 3279 breast specimens received over a period of 4 years (1993-1996) at the department of pathology, the Aga Khan University Hospital. RESULTS: Out of a total of 3279 breast specimens, common breast lesions included infiltrating duct carcinoma 37%, followed by fibro adenoma 16.95%, fibrocystic change 13.96%, mastitis 6.83% and duct ectasia 5.33%. Majority of the cases of infiltrating duct carcinoma were encountered in the 5th and 6th decades of life. Tumour size was 2 or >2 cms. in 93% of cases and 40% of them showed 3 or >3 positive lymph nodes. Grade I tumours were 11.38%, grade II 59.17% and grade III tumours 29.47%. Correlation of grade with lymph node metastases (3 or >3+ve nodes) showed 15 cases (1.53%) of grade I, 178 cases (18.25%) of grade II and 68 (6.97%) cases of grade III tumours. CONCLUSION: This study shows that in Pakistani females, the most commonly encountered lesion in carcinoma of the breast followed by the benign lesions such as fibro adenoma, fibrocystic disease & others. Breast carcinoma occurs at a younger age group with predominance of high-grade lesions and with frequent lymph node metastasis.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalJPMA. The Journal of the Pakistan Medical Association
Issue number3
Publication statusPublished - Mar 2003


Dive into the research topics of 'Breast diseases: a histopathological analysis of 3279 cases at a tertiary care center in Pakistan.'. Together they form a unique fingerprint.

Cite this