TY - JOUR
T1 - Burden and risk of neurological and cognitive impairment in pediatric sickle cell anemia in Uganda (BRAIN SAFE): Interim 0verall results.
AU - Green, Nancy
AU - Munube, Deogratias
AU - Mupere, Ezekiel
AU - Opoka, Robert
AU - Kasyrie, Philip
AU - Bangirana, Paul
AU - Buluma, Linda Rosset
AU - Kiguli, Sarah
AU - Kawooya, Michael
AU - Labowa, Samson
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Sickle Cell Anemia (SCA) is highly prevalent in sub-Saharan Africa (SSA). In Uganda, approximately 20,000 children are born with SCA annually (Ndeezi G, 2016). Sickle brain vasculopathy causes both overt strokes and clinically "silent infarcts," affecting neurological and cognitive function (DeBaun MR, 2012). Incidence of strokes has markedly decreased through standardized preventative measures. Study objectives are to determine the age-related spectrum and burden of brain injury associated with SCA in Ugandan children, determine predisposing risk factors and build capacity to support interventions for stroke prevention. Here we present preliminary results.
AB - Sickle Cell Anemia (SCA) is highly prevalent in sub-Saharan Africa (SSA). In Uganda, approximately 20,000 children are born with SCA annually (Ndeezi G, 2016). Sickle brain vasculopathy causes both overt strokes and clinically "silent infarcts," affecting neurological and cognitive function (DeBaun MR, 2012). Incidence of strokes has markedly decreased through standardized preventative measures. Study objectives are to determine the age-related spectrum and burden of brain injury associated with SCA in Ugandan children, determine predisposing risk factors and build capacity to support interventions for stroke prevention. Here we present preliminary results.
U2 - 10.1182/blood.V130.Suppl_1.979.979
DO - 10.1182/blood.V130.Suppl_1.979.979
M3 - Article
JO - Paediatrics and Child Health, East Africa
JF - Paediatrics and Child Health, East Africa
ER -