Burden of asthma among children in a developing megacity: Childhood asthma study, Pakistan

Adeel Ahmed Khan, Sana Tanzil, Tanzil Jamali, Afshan Shahid, Shahla Naeem, Ambreen Sahito, Fraz Anwar Siddiqui, Asaad Ahmed Nafees, Zafar Fatmi

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)


Objectives: Global burden of childhood asthma has increased in the past few decades, particularly in low-income countries. In Pakistan, there is a lack of community-based epidemiological studies estimating the burden of asthma among children. This study determined the prevalence and predictors of asthma among children 3-17 years of age in Karachi, Pakistan. Methods: A two-stage community-based representative cross-sectional survey was conducted in Karachi from March 2012 to April 2013 comprising 1046 children aged 3-17 years. Of 7500 clusters, 80 were randomly selected, and of these, 15 children per cluster were enrolled randomly. A translated and pre-tested version of International Study of Asthma and Allergies in Children questionnaire was administered. Results: The overall prevalence of asthma among study participants was 10.2% (95% CI: 8.4-12.0). Asthma was more likely to occur among boys (adj. OR: 2.5, 95% CI: 1.6-4.0), children in the younger age group (3-7 years) (adj. OR: 2.9, 95% CI: 1.7-4.8), those living in households with ill-ventilated kitchens (adj. OR: 1.8, 95% CI: 1.1-3.1), having family history of asthma (adj. OR: 2.3, 95% CI: 1.3-3.9) and those of the Sindhi ethnicity (adj. OR: 2.2, 95% CI: 1.1-4.4). Conclusion: This study is the first robust evidence regarding asthma among children in Pakistan, reporting a high burden in this group. Family history, male gender, Sindhi ethnicity and ill-ventilated kitchen were identified as important predictors of asthma. Targeted preventive measures and intervention studies are required to better understand and reduce the burden of asthma among children in Pakistan.

Original languageEnglish
Pages (from-to)891-899
Number of pages9
JournalJournal of Asthma
Issue number9
Publication statusPublished - 1 Nov 2014


  • Asthma
  • Children
  • ISAAC (International Study of Asthma and Allergies in Children) questionnaire
  • Pakistan
  • Prevalence and predictors


Dive into the research topics of 'Burden of asthma among children in a developing megacity: Childhood asthma study, Pakistan'. Together they form a unique fingerprint.

Cite this