Cadmium: Sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas

S. Kacew; Z. Merali; R. L. Singhal

doi:10.1016/0306-3623(76)90011-2

Cadmium: Sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas

S. Kacew, Z. Merali, R. L. Singhal

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

1. 1. Administration of cadmium (2 × 1.0 mg/kg/day) for 3 days produced a decrease in pancreatic RNA and DNA content, followed by a subsequent return to control values by the seventh day of treatment. 2. 2. The cadmium-inflicted alterations in nucleic acid levels were accompanied by an enhanced ability of the pancreas to incorporate ¹⁴C-thymidine into DNA. 3. 3. The cadmium-stimulated increase in pancreatic DNA synthesis appeared not to be associated with alterations in cyclic AMP and polyamine metabolism.

Original language	English (UK)
Pages (from-to)	433-435
Number of pages	3
Journal	Vascular Pharmacology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/0306-3623(76)90011-2
Publication status	Published - Dec 1976
Externally published	Yes

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title = "Cadmium: Sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas",

abstract = "1. 1. Administration of cadmium (2 × 1.0 mg/kg/day) for 3 days produced a decrease in pancreatic RNA and DNA content, followed by a subsequent return to control values by the seventh day of treatment. 2. 2. The cadmium-inflicted alterations in nucleic acid levels were accompanied by an enhanced ability of the pancreas to incorporate 14C-thymidine into DNA. 3. 3. The cadmium-stimulated increase in pancreatic DNA synthesis appeared not to be associated with alterations in cyclic AMP and polyamine metabolism.",

author = "S. Kacew and Z. Merali and Singhal, \{R. L.\}",

year = "1976",

month = dec,

doi = "10.1016/0306-3623(76)90011-2",

language = "English (UK)",

volume = "7",

pages = "433--435",

journal = "Vascular Pharmacology",

issn = "0306-3623",

publisher = "Elsevier Inc.",

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TY - JOUR

T1 - Cadmium

T2 - Sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas

AU - Kacew, S.

AU - Merali, Z.

AU - Singhal, R. L.

PY - 1976/12

Y1 - 1976/12

N2 - 1. 1. Administration of cadmium (2 × 1.0 mg/kg/day) for 3 days produced a decrease in pancreatic RNA and DNA content, followed by a subsequent return to control values by the seventh day of treatment. 2. 2. The cadmium-inflicted alterations in nucleic acid levels were accompanied by an enhanced ability of the pancreas to incorporate 14C-thymidine into DNA. 3. 3. The cadmium-stimulated increase in pancreatic DNA synthesis appeared not to be associated with alterations in cyclic AMP and polyamine metabolism.

AB - 1. 1. Administration of cadmium (2 × 1.0 mg/kg/day) for 3 days produced a decrease in pancreatic RNA and DNA content, followed by a subsequent return to control values by the seventh day of treatment. 2. 2. The cadmium-inflicted alterations in nucleic acid levels were accompanied by an enhanced ability of the pancreas to incorporate 14C-thymidine into DNA. 3. 3. The cadmium-stimulated increase in pancreatic DNA synthesis appeared not to be associated with alterations in cyclic AMP and polyamine metabolism.

UR - https://www.scopus.com/pages/publications/0017054149

U2 - 10.1016/0306-3623(76)90011-2

DO - 10.1016/0306-3623(76)90011-2

M3 - Article

C2 - 190083

AN - SCOPUS:0017054149

SN - 0306-3623

VL - 7

SP - 433

EP - 435

JO - Vascular Pharmacology

JF - Vascular Pharmacology

IS - 6

ER -

Cadmium: Sequential changes in nucleic acid synthesis as well as polyamines and cyclic AMP levels of rat pancreas

Abstract

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