Candida esophagitis: Risk factors in non-HIV population in Pakistan

Javed Yakoob, Wasim Jafri, Shahab Abid, Nadeem Jafri, Muhammad Islam, Saeed Hamid, Hasnain A. Shah, Akbar S. Hussainy

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Aim: Candida esophagitis is a frequent infection in immunocompromised patients. This study was designed to determine its characteristics in non- human immune deficiency virus (HIV) infected patients attending a teaching hospital. Methods: Clinical records of all patients coded by international classification of diseases 9th revision with clinical modifications' (ICD-9-CM), with Candida esophagitis diagnosed by esophagogastroduodenoscopy (EGD) and histopathology over a period of 5 years were studied. Results: Fifty-one patients (27 males, 24 females, range 21-77 years old and mean age 52.9 years) fulfilled the criteria (0.34 % of the EGD). The common predisposing factors were carcinoma (OR 3.87, CI 1.00-14.99) and diabetes mellitus (OR 4.39, CI 1.34-14.42). The frequent clinical symptoms were retrosternal discomfort, dysphagia and epigastric abdominal pain with endoscopic appearance of scattered mucosal plaques. Another endoscopic lesion was associated with Candida esophagitis in 15 % patients. Conclusion: Carcinomas, diabetes mellitus, corticosteroid and antibiotic therapy are major risk factors for Candida esophagitis in Pakistan. It is an easily managed complication that responds to treatment with nystatin.

Original languageEnglish
Pages (from-to)2328-2331
Number of pages4
JournalWorld Journal of Gastroenterology
Issue number10
Publication statusPublished - Oct 2003


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