TY - JOUR
T1 - Candida esophagitis
T2 - Risk factors in non-HIV population in Pakistan
AU - Yakoob, Javed
AU - Jafri, Wasim
AU - Abid, Shahab
AU - Jafri, Nadeem
AU - Islam, Muhammad
AU - Hamid, Saeed
AU - Shah, Hasnain A.
AU - Hussainy, Akbar S.
PY - 2003/10
Y1 - 2003/10
N2 - Aim: Candida esophagitis is a frequent infection in immunocompromised patients. This study was designed to determine its characteristics in non- human immune deficiency virus (HIV) infected patients attending a teaching hospital. Methods: Clinical records of all patients coded by international classification of diseases 9th revision with clinical modifications' (ICD-9-CM), with Candida esophagitis diagnosed by esophagogastroduodenoscopy (EGD) and histopathology over a period of 5 years were studied. Results: Fifty-one patients (27 males, 24 females, range 21-77 years old and mean age 52.9 years) fulfilled the criteria (0.34 % of the EGD). The common predisposing factors were carcinoma (OR 3.87, CI 1.00-14.99) and diabetes mellitus (OR 4.39, CI 1.34-14.42). The frequent clinical symptoms were retrosternal discomfort, dysphagia and epigastric abdominal pain with endoscopic appearance of scattered mucosal plaques. Another endoscopic lesion was associated with Candida esophagitis in 15 % patients. Conclusion: Carcinomas, diabetes mellitus, corticosteroid and antibiotic therapy are major risk factors for Candida esophagitis in Pakistan. It is an easily managed complication that responds to treatment with nystatin.
AB - Aim: Candida esophagitis is a frequent infection in immunocompromised patients. This study was designed to determine its characteristics in non- human immune deficiency virus (HIV) infected patients attending a teaching hospital. Methods: Clinical records of all patients coded by international classification of diseases 9th revision with clinical modifications' (ICD-9-CM), with Candida esophagitis diagnosed by esophagogastroduodenoscopy (EGD) and histopathology over a period of 5 years were studied. Results: Fifty-one patients (27 males, 24 females, range 21-77 years old and mean age 52.9 years) fulfilled the criteria (0.34 % of the EGD). The common predisposing factors were carcinoma (OR 3.87, CI 1.00-14.99) and diabetes mellitus (OR 4.39, CI 1.34-14.42). The frequent clinical symptoms were retrosternal discomfort, dysphagia and epigastric abdominal pain with endoscopic appearance of scattered mucosal plaques. Another endoscopic lesion was associated with Candida esophagitis in 15 % patients. Conclusion: Carcinomas, diabetes mellitus, corticosteroid and antibiotic therapy are major risk factors for Candida esophagitis in Pakistan. It is an easily managed complication that responds to treatment with nystatin.
UR - http://www.scopus.com/inward/record.url?scp=0142182238&partnerID=8YFLogxK
U2 - 10.3748/wjg.v9.i10.2328
DO - 10.3748/wjg.v9.i10.2328
M3 - Article
C2 - 14562403
AN - SCOPUS:0142182238
SN - 1007-9327
VL - 9
SP - 2328
EP - 2331
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
IS - 10
ER -
