TY - JOUR
T1 - Candidiasis
T2 - Prevalence and resistance profiling in a tertiary care hospital of Pakistan
AU - Jamil, Bushra
AU - Bokhari, Mohammad Tauseef Mukhtar
AU - Saeed, Azhar
AU - Bokhari, Mohammad Zahid Mukhtar
AU - Hussain, Zakir
AU - Khalid, Tayyaba
AU - Bokhari, Habib
AU - Imran, Mohammad
AU - Abbasi, Shahid Ahmad
N1 - Publisher Copyright:
© 2017, Pakistan Medical Association. All rights reserved.
PY - 2017/5
Y1 - 2017/5
N2 - Objective: To determine Candida colonisation/infection in renal transplant patients and to determine the resistance pattern against antifungal drugs. Method: This prospective, observational study was conducted at Al-Sayyed Hospital, Rawalpindi, Pakistan, from January to October 2014, in collaboration with the Microbiology and Public Health Laboratory's, Islamabad campus..The clinical specimens investigated included respiratory tract secretions, blood, urine, high vaginal swab, skin scrapings, and plastic devices samples. Results: Of the 7,850 samples, 164(2.08%) were positive for Candida. Candida albicans were most prevalent as they were found in 114(69%) samples. Besides, 56(34%) of the positive samples were resistant to one or more antifungal agents. Highest resistance was obtained against fluconazole. We found only 5(3.04%) positive samples of Candida glabrata; of them, 3(60%)were resistant. In case of Candida spp, 27(48%) resistance was observed. In Candida albicans, 23(41%) of the samples were found to be resistant. Most of the Candida isolates was recovered from bronchial alveolar lavage. Conclusion: Although Candida albicans remained the main responsible species for Candida infections, but non-albican Candida species are also emerging.
AB - Objective: To determine Candida colonisation/infection in renal transplant patients and to determine the resistance pattern against antifungal drugs. Method: This prospective, observational study was conducted at Al-Sayyed Hospital, Rawalpindi, Pakistan, from January to October 2014, in collaboration with the Microbiology and Public Health Laboratory's, Islamabad campus..The clinical specimens investigated included respiratory tract secretions, blood, urine, high vaginal swab, skin scrapings, and plastic devices samples. Results: Of the 7,850 samples, 164(2.08%) were positive for Candida. Candida albicans were most prevalent as they were found in 114(69%) samples. Besides, 56(34%) of the positive samples were resistant to one or more antifungal agents. Highest resistance was obtained against fluconazole. We found only 5(3.04%) positive samples of Candida glabrata; of them, 3(60%)were resistant. In case of Candida spp, 27(48%) resistance was observed. In Candida albicans, 23(41%) of the samples were found to be resistant. Most of the Candida isolates was recovered from bronchial alveolar lavage. Conclusion: Although Candida albicans remained the main responsible species for Candida infections, but non-albican Candida species are also emerging.
KW - Antifungal resistance
KW - Candidiasis
KW - Candiduria
KW - Chronic renal failure
KW - Non-albicans Candida
UR - http://www.scopus.com/inward/record.url?scp=85017275898&partnerID=8YFLogxK
M3 - Article
C2 - 28507352
AN - SCOPUS:85017275898
SN - 0030-9982
VL - 67
SP - 688
EP - 692
JO - Journal of the Pakistan Medical Association
JF - Journal of the Pakistan Medical Association
IS - 5
ER -
