Candidiasis: Prevalence and resistance profiling in a tertiary care hospital of Pakistan

Bushra Jamil, Mohammad Tauseef Mukhtar Bokhari, Azhar Saeed, Mohammad Zahid Mukhtar Bokhari, Zakir Hussain, Tayyaba Khalid, Habib Bokhari, Mohammad Imran, Shahid Ahmad Abbasi

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objective: To determine Candida colonisation/infection in renal transplant patients and to determine the resistance pattern against antifungal drugs. Method: This prospective, observational study was conducted at Al-Sayyed Hospital, Rawalpindi, Pakistan, from January to October 2014, in collaboration with the Microbiology and Public Health Laboratory's, Islamabad campus..The clinical specimens investigated included respiratory tract secretions, blood, urine, high vaginal swab, skin scrapings, and plastic devices samples. Results: Of the 7,850 samples, 164(2.08%) were positive for Candida. Candida albicans were most prevalent as they were found in 114(69%) samples. Besides, 56(34%) of the positive samples were resistant to one or more antifungal agents. Highest resistance was obtained against fluconazole. We found only 5(3.04%) positive samples of Candida glabrata; of them, 3(60%)were resistant. In case of Candida spp, 27(48%) resistance was observed. In Candida albicans, 23(41%) of the samples were found to be resistant. Most of the Candida isolates was recovered from bronchial alveolar lavage. Conclusion: Although Candida albicans remained the main responsible species for Candida infections, but non-albican Candida species are also emerging.

Original languageEnglish
Pages (from-to)688-692
Number of pages5
JournalJournal of the Pakistan Medical Association
Volume67
Issue number5
Publication statusPublished - May 2017
Externally publishedYes

Keywords

  • Antifungal resistance
  • Candidiasis
  • Candiduria
  • Chronic renal failure
  • Non-albicans Candida

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