Cardiac disease in beta-thalassaemia major: Is it reversible?

Mehnaz Atiq, M. Bana, U. S. Ahmed, S. Bano, M. Yousuf, Z. Fadoo, M. Khurshid

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)


Introduction: The aim of this study was to evaluate the spectrum of cardiac involvement and its outcome in beta-thalassaemia major. Methods: There were 75 patients with a mean age of 13.8 (+/- 5.5) years, of whom 33 were male and 42 were female. Clinical history, examination and laboratory investigations were assessed. Electrocardiograms, chest radiographs and echocardiograms were reviewed. Results: 44 patients had cardiac involvement in the form of left ventricular systolic dysfunction in 17, diastolic dysfunction in 22, pericardial effusion in 12 and pulmonary hypertension in 12 patients. With intense chelation therapy and cardiac medications, the condition of 13 of 17 patients with systolic dysfunction, and four of 22 with diastolic dysfunction, improved. Conclusion: Cardiac disease is a common complication of siderotic disease in thalassaemia major and it can be prevented with regular chelation. This study has shown improved systolic function after regular chelation therapy.

Original languageEnglish
Pages (from-to)693-696
Number of pages4
JournalSingapore Medical Journal
Issue number8
Publication statusPublished - Aug 2006


  • Cardiomyopathy
  • Chelation
  • Haemosiderosis
  • Left ventricular dysfunction
  • Thalassaemia major


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