Cardiovascular disease risk factors in Pakistani population with newly diagnosed Type 2 diabetes mellitus: A cross-sectional study of selected family practitioner clinics in four provinces of Pakistan (CardiP Study)

Syed Abbas Raza, Mariam Hassan, Farhana Badar, Farah Rasheed, Fouzia Meerza, Sumeyya Azam, Ali Jawa, Imtiaz Hassan, Faisal Masood Qureshi, Zakir Alvi, Saeed Ahmed Mahar, Azizul Hasan Aamir, Rauf Niazi, Najmul Islam

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

OBJECTIVE: To explore cardiovascular risk factors in people with newly-diagnosed type 2 diabetes mellitus. METHODS: The cross-sectional, prospective, multicentre, study was conducted from June 2014 till July 2015 at family practice clinics in 27 cities across Pakistan, and comprised individuals aged 30-50 years diagnosed with type 2 diabetes mellitus within the preceding six months. Laboratory investigations were conducted at Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, and Aga Khan University Hospital, Karachi. The 10-year absolute risk of fatal or non-fatal coronary heart disease and stroke was calculated using the United Kingdom Prospective Diabetes Study Risk Engine version 2.0. Data were analysed using SPSS 19. RESULTS: Out of 888 subjects, 362(40.8%) were women and 526(59.2%) were men. The overall mean presenting age was 42.4�}5.8 years. After stratification by age, those ≥40 years were significantly associated with higher glycated haemoglobin (p=0.02) and those ≤39 years were associated with higher levels of very low density lipoprotein (p=0.001) and triglyceride (p=0.006). The mean risk estimate for CHD was 9.7% (95% Confidence Interval (CI) 9.0- 10.1)), for fatal CHD 4.4% (95% CI 4.0-4.6), for stroke 1.5% (95% CI 1.2-1.7), and for fatal stroke 0.25% (95% CI 0.24- 0.26). CONCLUSIONS: There is a need for screening cardiovascular risk factors even in younger age groups of newlydiagnosed diabetes.

Original languageEnglish
Pages (from-to)306-312
Number of pages7
JournalJPMA. The Journal of the Pakistan Medical Association
Volume69
Issue number3
Publication statusPublished - 1 Mar 2019

Keywords

  • Type 2 diabetes mellitus, Cardiovascular disease, Dyslipidaemia, Risk factors.

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