Cardiovascular Dysfunction in Children Exposed to Preeclampsia During Fetal Life

Zahra Hoodbhoy, Nuruddin Mohammed, Shafquat Rozi, Nadeem Aslam, Shazia Mohsin, Salima Ashiqali, Hina Ali, Saima Sattar, Devyani Chowdhury, Babar Sultan Hasan

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Background: Keeping in view the developmental origin of health and disease hypothesis, the aim of this study was to assess differences in cardiac and vascular structure and function in children exposed to preeclampsia in utero compared with those of normotensive mothers. The hypothesis under investigation was that children exposed to preeclampsia would have altered cardiac and vascular structure and function compared with the unexposed group. Methods: This was a retrospective cohort study that included children 2 to 10 years of age born to mothers with and without exposure to preeclampsia in utero (n = 80 in each group). Myocardial morphology and function using echocardiography and carotid intima-media thickness and pulse-wave velocity were determined. Multivariate linear regression was used to compare preeclampsia-exposed and nonexposed groups. Subgroup analysis to assess differences between early- and late-onset preeclampsia was also performed. Results: Forty-one percent of mothers (n = 33) had early-onset preeclampsia. Children in the exposed group had a significantly higher prevalence of stage 1 systolic and diastolic hypertension (22% [n = 18] and 35% [n = 18], respectively) compared with the unexposed group (9% [n = 7] and 19% [n = 15], respectively; P =.01). Children in the exposed group also had higher pulse-wave velocity compared with those in the unexposed group (0.42 ± 0.1 vs 0.39 ± 0.1, P =.03). Subgroup analysis revealed that changes in blood pressure and pulse-wave velocity were determined primarily by early-onset preeclampsia. There was no significant difference in cardiac morphology or systolic and diastolic function between the exposed and unexposed groups. Conclusion: In utero exposure to preeclampsia has an effect on vascular function in children aged 2 to 10 years, related primarily to early-onset disease. Routine blood pressure screening should be recommended for such children.

Original languageEnglish
Pages (from-to)653-661
Number of pages9
JournalJournal of the American Society of Echocardiography
Issue number6
Publication statusPublished - Jun 2021


  • Cardiovascular disease
  • Children
  • Preeclampsia
  • Risk assessment


Dive into the research topics of 'Cardiovascular Dysfunction in Children Exposed to Preeclampsia During Fetal Life'. Together they form a unique fingerprint.

Cite this