Cardiovascular inhibitory effects of Hyoscyamus niger

A. U. Khan; Anwarul Hassan Gilani

doi:10.1358/mf.2008.30.4.1186075

Cardiovascular inhibitory effects of Hyoscyamus niger

A. U. Khan, Anwarul Hassan Gilani

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The study describes the hypotensive, cardiosuppressant and vasodilator activities of Hyoscyamus niger crude extract (Hn.Cr). Hn.Cr, which tested positive for alkaloids, coumarins, flavonoids, sterols, tannins and terpenes, caused a dose-dependent (10-100 mg/kg) fall in the arterial blood pressure (BP) of rats under anesthesia. In guinea-pig atria, Hn.Cr exhibited a cardiodepressant effect on the rate and force of spontaneous atrial contractions. In isolated rabbit aorta, Hn.Cr (0.01-1.0 mg/ml) relaxed the phenylephrine (PE, 1 μM) and K⁺ (80 mM)-induced contractions and suppressed PE (1 μ) control peaks obtained in Ca⁺⁺-free medium similar to that caused by verapamil. The vasodilator effect of Hn.Cr was endothelium-independent as it was not opposed by N_ω-nitro-L-arginine methyl ester in endothelium-intact rat aortic preparations and also occurred at a similar concentration in endothelium-denuded tissues. These data indicate that Hyoscyamus niger lowers BP through a Ca⁺⁺-antagonist mechanism.

Original language	English
Pages (from-to)	295-300
Number of pages	6
Journal	Methods and Findings in Experimental and Clinical Pharmacology
Volume	30
Issue number	4
DOIs	https://doi.org/10.1358/mf.2008.30.4.1186075
Publication status	Published - May 2008
Externally published	Yes

Keywords

Calcium antagonist
Cardiodepressant
Hyoscyamus niger
Hypotensive
Vasodilator

Access to Document

10.1358/mf.2008.30.4.1186075

Cite this

@article{dad97a5646614565a0c448ab47c6649e,

title = "Cardiovascular inhibitory effects of Hyoscyamus niger",

abstract = "The study describes the hypotensive, cardiosuppressant and vasodilator activities of Hyoscyamus niger crude extract (Hn.Cr). Hn.Cr, which tested positive for alkaloids, coumarins, flavonoids, sterols, tannins and terpenes, caused a dose-dependent (10-100 mg/kg) fall in the arterial blood pressure (BP) of rats under anesthesia. In guinea-pig atria, Hn.Cr exhibited a cardiodepressant effect on the rate and force of spontaneous atrial contractions. In isolated rabbit aorta, Hn.Cr (0.01-1.0 mg/ml) relaxed the phenylephrine (PE, 1 μM) and K+ (80 mM)-induced contractions and suppressed PE (1 μ) control peaks obtained in Ca++-free medium similar to that caused by verapamil. The vasodilator effect of Hn.Cr was endothelium-independent as it was not opposed by Nω-nitro-L-arginine methyl ester in endothelium-intact rat aortic preparations and also occurred at a similar concentration in endothelium-denuded tissues. These data indicate that Hyoscyamus niger lowers BP through a Ca++-antagonist mechanism.",

keywords = "Calcium antagonist, Cardiodepressant, Hyoscyamus niger, Hypotensive, Vasodilator",

author = "Khan, {A. U.} and Gilani, {Anwarul Hassan}",

year = "2008",

month = may,

doi = "10.1358/mf.2008.30.4.1186075",

language = "English",

volume = "30",

pages = "295--300",

journal = "Methods and Findings in Experimental and Clinical Pharmacology",

issn = "0379-0355",

publisher = "Prous Science",

number = "4",

}

TY - JOUR

T1 - Cardiovascular inhibitory effects of Hyoscyamus niger

AU - Khan, A. U.

AU - Gilani, Anwarul Hassan

PY - 2008/5

Y1 - 2008/5

N2 - The study describes the hypotensive, cardiosuppressant and vasodilator activities of Hyoscyamus niger crude extract (Hn.Cr). Hn.Cr, which tested positive for alkaloids, coumarins, flavonoids, sterols, tannins and terpenes, caused a dose-dependent (10-100 mg/kg) fall in the arterial blood pressure (BP) of rats under anesthesia. In guinea-pig atria, Hn.Cr exhibited a cardiodepressant effect on the rate and force of spontaneous atrial contractions. In isolated rabbit aorta, Hn.Cr (0.01-1.0 mg/ml) relaxed the phenylephrine (PE, 1 μM) and K+ (80 mM)-induced contractions and suppressed PE (1 μ) control peaks obtained in Ca++-free medium similar to that caused by verapamil. The vasodilator effect of Hn.Cr was endothelium-independent as it was not opposed by Nω-nitro-L-arginine methyl ester in endothelium-intact rat aortic preparations and also occurred at a similar concentration in endothelium-denuded tissues. These data indicate that Hyoscyamus niger lowers BP through a Ca++-antagonist mechanism.

AB - The study describes the hypotensive, cardiosuppressant and vasodilator activities of Hyoscyamus niger crude extract (Hn.Cr). Hn.Cr, which tested positive for alkaloids, coumarins, flavonoids, sterols, tannins and terpenes, caused a dose-dependent (10-100 mg/kg) fall in the arterial blood pressure (BP) of rats under anesthesia. In guinea-pig atria, Hn.Cr exhibited a cardiodepressant effect on the rate and force of spontaneous atrial contractions. In isolated rabbit aorta, Hn.Cr (0.01-1.0 mg/ml) relaxed the phenylephrine (PE, 1 μM) and K+ (80 mM)-induced contractions and suppressed PE (1 μ) control peaks obtained in Ca++-free medium similar to that caused by verapamil. The vasodilator effect of Hn.Cr was endothelium-independent as it was not opposed by Nω-nitro-L-arginine methyl ester in endothelium-intact rat aortic preparations and also occurred at a similar concentration in endothelium-denuded tissues. These data indicate that Hyoscyamus niger lowers BP through a Ca++-antagonist mechanism.

KW - Calcium antagonist

KW - Cardiodepressant

KW - Hyoscyamus niger

KW - Hypotensive

KW - Vasodilator

UR - http://www.scopus.com/inward/record.url?scp=52649131241&partnerID=8YFLogxK

U2 - 10.1358/mf.2008.30.4.1186075

DO - 10.1358/mf.2008.30.4.1186075

M3 - Article

C2 - 18773124

AN - SCOPUS:52649131241

SN - 0379-0355

VL - 30

SP - 295

EP - 300

JO - Methods and Findings in Experimental and Clinical Pharmacology

JF - Methods and Findings in Experimental and Clinical Pharmacology

IS - 4

ER -

Cardiovascular inhibitory effects of Hyoscyamus niger

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this