Case definition of chronic pulmonary aspergillosis in resource-constrained settings

David W. Denning; Iain D. Page; Jeremiah Chakaya; Kauser Jabeen; Cecilia M. Jude; Muriel Cornet; Ana Alastruey-Izquierdo; Felix Bongomin; Paul Bowyer; Arunaloke Chakrabarti; Sara Gago; John Guto; Bruno Hochhegger; Martin Hoenigl; Muhammad Irfan; Nicholas Irurhe; Koichi Izumikawa; Bruce Kirenga; Veronica Manduku; Samihah Moazam; Rita O. Oladele; Malcolm D. Richardson; Juan Luis Rodriguez Tudela; Anna Rozaliyani; Helmut J.F. Salzer; Richard Sawyer; Nasilele F. Simukulwa; Alena Skrahina; Charlotte Sriruttan; Findra Setianingrum; Bayu A.P. Wilopo; Donald C. Cole; Haileyesus Getahun

doi:10.3201/eid2408.171312

Case definition of chronic pulmonary aspergillosis in resource-constrained settings

David W. Denning, Iain D. Page, Jeremiah Chakaya, Kauser Jabeen, Cecilia M. Jude, Muriel Cornet, Ana Alastruey-Izquierdo, Felix Bongomin, Paul Bowyer, Arunaloke Chakrabarti, Sara Gago, John Guto, Bruno Hochhegger, Martin Hoenigl, Muhammad Irfan, Nicholas Irurhe, Koichi Izumikawa, Bruce Kirenga, Veronica Manduku, Samihah MoazamRita O. Oladele, Malcolm D. Richardson, Juan Luis Rodriguez Tudela, Anna Rozaliyani, Helmut J.F. Salzer, Richard Sawyer, Nasilele F. Simukulwa, Alena Skrahina, Charlotte Sriruttan, Findra Setianingrum, Bayu A.P. Wilopo, Donald C. Cole, Haileyesus Getahun

Research output: Contribution to journal › Article › peer-review

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Abstract

Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower-and middle-income countries as well as in resource-constrained settings.

Original language	English
Pages (from-to)	e1-e13
Journal	Emerging Infectious Diseases
Volume	24
Issue number	8
DOIs	https://doi.org/10.3201/eid2408.171312
Publication status	Published - Aug 2018

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Denning, D. W., Page, I. D., Chakaya, J., Jabeen, K., Jude, C. M., Cornet, M., Alastruey-Izquierdo, A., Bongomin, F., Bowyer, P., Chakrabarti, A., Gago, S., Guto, J., Hochhegger, B., Hoenigl, M., Irfan, M., Irurhe, N., Izumikawa, K., Kirenga, B., Manduku, V., ... Getahun, H. (2018). Case definition of chronic pulmonary aspergillosis in resource-constrained settings. Emerging Infectious Diseases, 24(8), e1-e13. https://doi.org/10.3201/eid2408.171312

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title = "Case definition of chronic pulmonary aspergillosis in resource-constrained settings",

abstract = "Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower-and middle-income countries as well as in resource-constrained settings.",

author = "Denning, {David W.} and Page, {Iain D.} and Jeremiah Chakaya and Kauser Jabeen and Jude, {Cecilia M.} and Muriel Cornet and Ana Alastruey-Izquierdo and Felix Bongomin and Paul Bowyer and Arunaloke Chakrabarti and Sara Gago and John Guto and Bruno Hochhegger and Martin Hoenigl and Muhammad Irfan and Nicholas Irurhe and Koichi Izumikawa and Bruce Kirenga and Veronica Manduku and Samihah Moazam and Oladele, {Rita O.} and Richardson, {Malcolm D.} and {Rodriguez Tudela}, {Juan Luis} and Anna Rozaliyani and Salzer, {Helmut J.F.} and Richard Sawyer and Simukulwa, {Nasilele F.} and Alena Skrahina and Charlotte Sriruttan and Findra Setianingrum and Wilopo, {Bayu A.P.} and Cole, {Donald C.} and Haileyesus Getahun",

year = "2018",

month = aug,

doi = "10.3201/eid2408.171312",

language = "English",

volume = "24",

pages = "e1--e13",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

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Denning, DW, Page, ID, Chakaya, J, Jabeen, K, Jude, CM, Cornet, M, Alastruey-Izquierdo, A, Bongomin, F, Bowyer, P, Chakrabarti, A, Gago, S, Guto, J, Hochhegger, B, Hoenigl, M, Irfan, M, Irurhe, N, Izumikawa, K, Kirenga, B, Manduku, V, Moazam, S, Oladele, RO, Richardson, MD, Rodriguez Tudela, JL, Rozaliyani, A, Salzer, HJF, Sawyer, R, Simukulwa, NF, Skrahina, A, Sriruttan, C, Setianingrum, F, Wilopo, BAP, Cole, DC & Getahun, H 2018, 'Case definition of chronic pulmonary aspergillosis in resource-constrained settings', Emerging Infectious Diseases, vol. 24, no. 8, pp. e1-e13. https://doi.org/10.3201/eid2408.171312

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T1 - Case definition of chronic pulmonary aspergillosis in resource-constrained settings

AU - Denning, David W.

AU - Page, Iain D.

AU - Chakaya, Jeremiah

AU - Jabeen, Kauser

AU - Jude, Cecilia M.

AU - Cornet, Muriel

AU - Alastruey-Izquierdo, Ana

AU - Bongomin, Felix

AU - Bowyer, Paul

AU - Chakrabarti, Arunaloke

AU - Gago, Sara

AU - Guto, John

AU - Hochhegger, Bruno

AU - Hoenigl, Martin

AU - Irfan, Muhammad

AU - Irurhe, Nicholas

AU - Izumikawa, Koichi

AU - Kirenga, Bruce

AU - Manduku, Veronica

AU - Moazam, Samihah

AU - Oladele, Rita O.

AU - Richardson, Malcolm D.

AU - Rodriguez Tudela, Juan Luis

AU - Rozaliyani, Anna

AU - Salzer, Helmut J.F.

AU - Sawyer, Richard

AU - Simukulwa, Nasilele F.

AU - Skrahina, Alena

AU - Sriruttan, Charlotte

AU - Setianingrum, Findra

AU - Wilopo, Bayu A.P.

AU - Cole, Donald C.

AU - Getahun, Haileyesus

PY - 2018/8

Y1 - 2018/8

N2 - Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower-and middle-income countries as well as in resource-constrained settings.

AB - Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower-and middle-income countries as well as in resource-constrained settings.

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VL - 24

SP - e1-e13

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

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ER -

Case definition of chronic pulmonary aspergillosis in resource-constrained settings

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