Cerebral venous sinus thrombosis

Golnaz Yadollahikhales, Afshin Borhani-Haghighi, Anahid Safari, Mohammad Wasay, Randall Edgell

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Cerebral venous thrombosis (CVT) is occlusion of dural sinuses and/or cortical veins due to clot formation. It is a potentially life-threatening condition that requires rapid diagnosis and urgent treatment. Cerebral venous thrombosis is more common in females and young people. Pregnancy, postpartum state, contraceptive pills, infection, malignancy, hyper-coagulable state, rheumatological disorders, trauma are among the major etiologies of cerebral venous thrombosis. Headache, focal neurologic deficits and seizure were the most common clinical presentations. Different techniques of unenhanced and contrast enhanced brain computerized tomography (CT scan) and, magnetic resonance imaging (MRI) are the most helpful ancillary investigations for diagnosis of Cerebral venous thrombosis. Specific treatment of the underlying cause of cerebral venous thrombosis should be considered as the mainstay of the treatment. Anticoagulation with heparin or low molecular weight heparinoids is the most accepted treatment. In acute phase, medical or surgical management to decrease intracranial pressure (ICP) is also recommended. If the patient's clinical condition aggravates despite adequate anticoagulation, thrombolysis or mechanical thrombectomy can be an additive option.

Original languageEnglish
Pages (from-to)48-61
Number of pages14
JournalGalen Medical Journal
Issue numberSpecialissue
Publication statusPublished - 2016


  • Cerebral venous thrombosis
  • Hypercoagulable disorders
  • Stroke
  • Virchow's triad


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