Developing countries disproportionally suffer from mortality and morbidity especially for children. Research leading to scientific progress in understanding causes of death has resulted in reduction in child morbidity and mortality in developed nations. However due to resource limitations, human and otherwise, in developing countries the progress towards achieving development goals, has been minimal. The collaborations and partnerships between developed and developing nations provides multiple opportunities for research and thereby learning, leading to reduction in child mortality. The scientists in both developed and developing nations need to understand the challenges that may occur while conducting research. In this paper we provide a framework for the researchers in both developing and developed nations to try to understand and develop research agenda and ideas that could not only address child health problems in developing countries but could also result in the progress of science benefitting the world at large.