Challenges in defining and classifying the preterm birth syndrome

Michael S. Kramer; Aris Papageorghiou; Jennifer Culhane; Zulfiqar Bhutta; Robert L. Goldenberg; Michael Gravett; Jay D. Iams; Agustin Conde-Agudelo; Sarah Waller; Fernando Barros; Hannah Knight; Jose Villar

doi:10.1016/j.ajog.2011.10.864

Challenges in defining and classifying the preterm birth syndrome

Michael S. Kramer, Aris Papageorghiou, Jennifer Culhane, Zulfiqar Bhutta, Robert L. Goldenberg, Michael Gravett, Jay D. Iams, Agustin Conde-Agudelo, Sarah Waller, Fernando Barros, Hannah Knight, Jose Villar

Institute for Global Health and Development, Pakistan

Research output: Contribution to journal › Article › peer-review

152 Citations (Scopus)

Abstract

In 2009, the Global Alliance to Prevent Prematurity and Stillbirth Conference charged the authors to propose a new comprehensive, consistent, and uniform classification system for preterm birth. This first article reviews issues related to measurement of gestational age, clinical vs etiologic phenotypes, inclusion vs exclusion of multifetal and stillborn infants, and separation vs combination of pathways to preterm birth. The second article proposes answers to the questions raised here, and the third demonstrates how the proposed system might work in practice.

Original language	English
Pages (from-to)	108-112
Number of pages	5
Journal	American Journal of Obstetrics and Gynecology
Volume	206
Issue number	2
DOIs	https://doi.org/10.1016/j.ajog.2011.10.864
Publication status	Published - Feb 2012

Keywords

classification
phenotype
preterm birth

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10.1016/j.ajog.2011.10.864

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title = "Challenges in defining and classifying the preterm birth syndrome",

abstract = "In 2009, the Global Alliance to Prevent Prematurity and Stillbirth Conference charged the authors to propose a new comprehensive, consistent, and uniform classification system for preterm birth. This first article reviews issues related to measurement of gestational age, clinical vs etiologic phenotypes, inclusion vs exclusion of multifetal and stillborn infants, and separation vs combination of pathways to preterm birth. The second article proposes answers to the questions raised here, and the third demonstrates how the proposed system might work in practice.",

keywords = "classification, phenotype, preterm birth",

author = "Kramer, {Michael S.} and Aris Papageorghiou and Jennifer Culhane and Zulfiqar Bhutta and Goldenberg, {Robert L.} and Michael Gravett and Iams, {Jay D.} and Agustin Conde-Agudelo and Sarah Waller and Fernando Barros and Hannah Knight and Jose Villar",

note = "Funding Information: This study was supported by the Bill and Melinda Gates Foundation and the Global Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle Children's Hospital, and by INTERGROWTH-21st grant 49038 from the Bill and Melinda Gates Foundation (to the University of Oxford, Oxford, United Kingdom). ",

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AU - Papageorghiou, Aris

AU - Culhane, Jennifer

AU - Bhutta, Zulfiqar

AU - Goldenberg, Robert L.

AU - Gravett, Michael

AU - Iams, Jay D.

AU - Conde-Agudelo, Agustin

AU - Waller, Sarah

AU - Barros, Fernando

AU - Knight, Hannah

AU - Villar, Jose

N1 - Funding Information: This study was supported by the Bill and Melinda Gates Foundation and the Global Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle Children's Hospital, and by INTERGROWTH-21st grant 49038 from the Bill and Melinda Gates Foundation (to the University of Oxford, Oxford, United Kingdom).

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N2 - In 2009, the Global Alliance to Prevent Prematurity and Stillbirth Conference charged the authors to propose a new comprehensive, consistent, and uniform classification system for preterm birth. This first article reviews issues related to measurement of gestational age, clinical vs etiologic phenotypes, inclusion vs exclusion of multifetal and stillborn infants, and separation vs combination of pathways to preterm birth. The second article proposes answers to the questions raised here, and the third demonstrates how the proposed system might work in practice.

AB - In 2009, the Global Alliance to Prevent Prematurity and Stillbirth Conference charged the authors to propose a new comprehensive, consistent, and uniform classification system for preterm birth. This first article reviews issues related to measurement of gestational age, clinical vs etiologic phenotypes, inclusion vs exclusion of multifetal and stillborn infants, and separation vs combination of pathways to preterm birth. The second article proposes answers to the questions raised here, and the third demonstrates how the proposed system might work in practice.

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Challenges in defining and classifying the preterm birth syndrome

Abstract

Keywords

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