Challenges in defining and classifying the preterm birth syndrome

Michael S. Kramer, Aris Papageorghiou, Jennifer Culhane, Zulfiqar Bhutta, Robert L. Goldenberg, Michael Gravett, Jay D. Iams, Agustin Conde-Agudelo, Sarah Waller, Fernando Barros, Hannah Knight, Jose Villar

Research output: Contribution to journalArticlepeer-review

148 Citations (Scopus)


In 2009, the Global Alliance to Prevent Prematurity and Stillbirth Conference charged the authors to propose a new comprehensive, consistent, and uniform classification system for preterm birth. This first article reviews issues related to measurement of gestational age, clinical vs etiologic phenotypes, inclusion vs exclusion of multifetal and stillborn infants, and separation vs combination of pathways to preterm birth. The second article proposes answers to the questions raised here, and the third demonstrates how the proposed system might work in practice.

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Issue number2
Publication statusPublished - Feb 2012


  • classification
  • phenotype
  • preterm birth


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