Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status

Zahra Hasan; N. Salahuddin; N. Rao; M. Aqeel; F. Mahmood; F. Ali; M. Ashraf; F. Rahman; S. Mahmood; M. Islam; B. Dildar; T. Anwer; F. Oiighor; N. Sharif; A. R. Ullah

doi:10.5588/ijtld.13.0460

Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status

Zahra Hasan, N. Salahuddin, N. Rao, M. Aqeel, F. Mahmood, F. Ali, M. Ashraf, F. Rahman, S. Mahmood, M. Islam, B. Dildar, T. Anwer, F. Oiighor, N. Sharif, A. R. Ullah

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Serum levels of the inflammatory C-X-C motif chemokine 10 (CXCL10) are raised in tuberculosis (TB). CXCL10 gene expression is downregulated in monocytes by metabolically active vitamin D₃ (1,25dihydroxy vitamin D). Stratification of patients by serum 25hydroxyvitamin D (25[OH]D) levels at baseline showed that treatment-induced decrease in CXCL10 occurred in those with 'insufficient' and 'deficient' but not in those with 'optimal' levels. In the deficient group, 25(OH)D showed an inverse correlation with CXCL10 levels. CXCL10 may thus be a useful biomarker for the follow-up of response to treatment. However, CXCL10 levels should be interpreted taking into account the baseline serum vitamin D levels of the TB patients.

Original language	English
Pages (from-to)	466-469
Number of pages	4
Journal	International Journal of Tuberculosis and Lung Disease
Volume	18
Issue number	4
DOIs	https://doi.org/10.5588/ijtld.13.0460
Publication status	Published - Apr 2014

Keywords

Biomarker
CXCL10
Tuberculosis
Vitamin D

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.5588/ijtld.13.0460

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Hasan, Z., Salahuddin, N., Rao, N., Aqeel, M., Mahmood, F., Ali, F., Ashraf, M., Rahman, F., Mahmood, S., Islam, M., Dildar, B., Anwer, T., Oiighor, F., Sharif, N., & Ullah, A. R. (2014). Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status. International Journal of Tuberculosis and Lung Disease, 18(4), 466-469. https://doi.org/10.5588/ijtld.13.0460

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title = "Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status",

abstract = "Serum levels of the inflammatory C-X-C motif chemokine 10 (CXCL10) are raised in tuberculosis (TB). CXCL10 gene expression is downregulated in monocytes by metabolically active vitamin D3 (1,25dihydroxy vitamin D). Stratification of patients by serum 25hydroxyvitamin D (25[OH]D) levels at baseline showed that treatment-induced decrease in CXCL10 occurred in those with 'insufficient' and 'deficient' but not in those with 'optimal' levels. In the deficient group, 25(OH)D showed an inverse correlation with CXCL10 levels. CXCL10 may thus be a useful biomarker for the follow-up of response to treatment. However, CXCL10 levels should be interpreted taking into account the baseline serum vitamin D levels of the TB patients.",

keywords = "Biomarker, CXCL10, Tuberculosis, Vitamin D",

author = "Zahra Hasan and N. Salahuddin and N. Rao and M. Aqeel and F. Mahmood and F. Ali and M. Ashraf and F. Rahman and S. Mahmood and M. Islam and B. Dildar and T. Anwer and F. Oiighor and N. Sharif and Ullah, {A. R.}",

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Hasan, Z, Salahuddin, N, Rao, N, Aqeel, M, Mahmood, F, Ali, F, Ashraf, M, Rahman, F, Mahmood, S, Islam, M, Dildar, B, Anwer, T, Oiighor, F, Sharif, N & Ullah, AR 2014, 'Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status', International Journal of Tuberculosis and Lung Disease, vol. 18, no. 4, pp. 466-469. https://doi.org/10.5588/ijtld.13.0460

TY - JOUR

T1 - Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status

AU - Hasan, Zahra

AU - Salahuddin, N.

AU - Rao, N.

AU - Aqeel, M.

AU - Mahmood, F.

AU - Ali, F.

AU - Ashraf, M.

AU - Rahman, F.

AU - Mahmood, S.

AU - Islam, M.

AU - Dildar, B.

AU - Anwer, T.

AU - Oiighor, F.

AU - Sharif, N.

AU - Ullah, A. R.

PY - 2014/4

Y1 - 2014/4

N2 - Serum levels of the inflammatory C-X-C motif chemokine 10 (CXCL10) are raised in tuberculosis (TB). CXCL10 gene expression is downregulated in monocytes by metabolically active vitamin D3 (1,25dihydroxy vitamin D). Stratification of patients by serum 25hydroxyvitamin D (25[OH]D) levels at baseline showed that treatment-induced decrease in CXCL10 occurred in those with 'insufficient' and 'deficient' but not in those with 'optimal' levels. In the deficient group, 25(OH)D showed an inverse correlation with CXCL10 levels. CXCL10 may thus be a useful biomarker for the follow-up of response to treatment. However, CXCL10 levels should be interpreted taking into account the baseline serum vitamin D levels of the TB patients.

AB - Serum levels of the inflammatory C-X-C motif chemokine 10 (CXCL10) are raised in tuberculosis (TB). CXCL10 gene expression is downregulated in monocytes by metabolically active vitamin D3 (1,25dihydroxy vitamin D). Stratification of patients by serum 25hydroxyvitamin D (25[OH]D) levels at baseline showed that treatment-induced decrease in CXCL10 occurred in those with 'insufficient' and 'deficient' but not in those with 'optimal' levels. In the deficient group, 25(OH)D showed an inverse correlation with CXCL10 levels. CXCL10 may thus be a useful biomarker for the follow-up of response to treatment. However, CXCL10 levels should be interpreted taking into account the baseline serum vitamin D levels of the TB patients.

KW - Biomarker

KW - CXCL10

KW - Tuberculosis

KW - Vitamin D

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U2 - 10.5588/ijtld.13.0460

DO - 10.5588/ijtld.13.0460

M3 - Article

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AN - SCOPUS:84897131875

SN - 1027-3719

VL - 18

SP - 466

EP - 469

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 4

ER -

Change in serum CXCL10 levels during anti-tuberculosis treatment depends on vitamin D status

Abstract

Keywords

UN SDGs

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