Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6

Anjali Prabhu, Hilary G. Morrison, Charles R. Martinez, Rodney D. Adam

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Giardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with telomeric sequence at one end to identify six subtelomeric regions in addition to previously identified subtelomeric regions, to study the telomeric arrangement of the chromosomes. The subtelomeric regions included two retroposons, one retroposon pseudogene, and two vsp genes, in addition to the previously identified subtelomeric regions that include ribosomal DNA repeats. The presence of vsp genes in a subtelomeric region suggests that telomeric rearrangements may contribute to the generation of vsp diversity. These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure.

Original languageEnglish
Pages (from-to)503-513
Number of pages11
JournalInternational Journal for Parasitology
Volume37
Issue number5
DOIs
Publication statusPublished - Apr 2007
Externally publishedYes

Keywords

  • Giardia lamblia
  • Retroposon
  • Subtelomeric region
  • Telomere
  • vsp

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