Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6

Anjali Prabhu; Hilary G. Morrison; Charles R. Martinez; Rodney D. Adam

doi:10.1016/j.ijpara.2006.12.011

Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6

Anjali Prabhu, Hilary G. Morrison, Charles R. Martinez, Rodney D. Adam

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Giardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with telomeric sequence at one end to identify six subtelomeric regions in addition to previously identified subtelomeric regions, to study the telomeric arrangement of the chromosomes. The subtelomeric regions included two retroposons, one retroposon pseudogene, and two vsp genes, in addition to the previously identified subtelomeric regions that include ribosomal DNA repeats. The presence of vsp genes in a subtelomeric region suggests that telomeric rearrangements may contribute to the generation of vsp diversity. These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure.

Original language	English
Pages (from-to)	503-513
Number of pages	11
Journal	International Journal for Parasitology
Volume	37
Issue number	5
DOIs	https://doi.org/10.1016/j.ijpara.2006.12.011
Publication status	Published - Apr 2007
Externally published	Yes

Keywords

Giardia lamblia
Retroposon
Subtelomeric region
Telomere
vsp

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijpara.2006.12.011

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title = "Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6",

abstract = "Giardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with telomeric sequence at one end to identify six subtelomeric regions in addition to previously identified subtelomeric regions, to study the telomeric arrangement of the chromosomes. The subtelomeric regions included two retroposons, one retroposon pseudogene, and two vsp genes, in addition to the previously identified subtelomeric regions that include ribosomal DNA repeats. The presence of vsp genes in a subtelomeric region suggests that telomeric rearrangements may contribute to the generation of vsp diversity. These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure.",

keywords = "Giardia lamblia, Retroposon, Subtelomeric region, Telomere, vsp",

author = "Anjali Prabhu and Morrison, {Hilary G.} and Martinez, {Charles R.} and Adam, {Rodney D.}",

note = "Funding Information: This work was supported in part by NIH Grant AI43273 to Mitchell L. Sogin. Additional support was provided by the G. Unger Vetlesen Foundation and LI-COR Biotechnology. Sequences that are part of the genome project can be accessed at the web site: www.mbl.edu/ Giardia .",

year = "2007",

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doi = "10.1016/j.ijpara.2006.12.011",

language = "English",

volume = "37",

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AU - Prabhu, Anjali

AU - Morrison, Hilary G.

AU - Martinez, Charles R.

AU - Adam, Rodney D.

N1 - Funding Information: This work was supported in part by NIH Grant AI43273 to Mitchell L. Sogin. Additional support was provided by the G. Unger Vetlesen Foundation and LI-COR Biotechnology. Sequences that are part of the genome project can be accessed at the web site: www.mbl.edu/ Giardia .

PY - 2007/4

Y1 - 2007/4

N2 - Giardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with telomeric sequence at one end to identify six subtelomeric regions in addition to previously identified subtelomeric regions, to study the telomeric arrangement of the chromosomes. The subtelomeric regions included two retroposons, one retroposon pseudogene, and two vsp genes, in addition to the previously identified subtelomeric regions that include ribosomal DNA repeats. The presence of vsp genes in a subtelomeric region suggests that telomeric rearrangements may contribute to the generation of vsp diversity. These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure.

AB - Giardia trophozoites are polyploid and have five chromosomes. The chromosome homologues demonstrate considerable size heterogeneity due to variation in the subtelomeric regions. We used clones from the genome project with telomeric sequence at one end to identify six subtelomeric regions in addition to previously identified subtelomeric regions, to study the telomeric arrangement of the chromosomes. The subtelomeric regions included two retroposons, one retroposon pseudogene, and two vsp genes, in addition to the previously identified subtelomeric regions that include ribosomal DNA repeats. The presence of vsp genes in a subtelomeric region suggests that telomeric rearrangements may contribute to the generation of vsp diversity. These studies of the subtelomeric regions of Giardia may contribute to our understanding of the factors that maintain stability, while allowing diversity in chromosome structure.

KW - Giardia lamblia

KW - Retroposon

KW - Subtelomeric region

KW - Telomere

KW - vsp

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DO - 10.1016/j.ijpara.2006.12.011

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SN - 0020-7519

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SP - 503

EP - 513

JO - International Journal for Parasitology

JF - International Journal for Parasitology

IS - 5

ER -

Characterisation of the subtelomeric regions of Giardia lamblia genome isolate WBC6

Abstract

Keywords

UN SDGs

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