Characteristics and outcomes of cerebral venous thrombosis associated with COVID-19

Adrian Scutelnic, Anita van de Munckhof, Angel T. Miraclin, Sanjith Aaron, Sajid Hameed, Mohammad Wasay, Oxana Grosu, Katarzyna Krzywicka, Mayte Sánchez van Kammen, Erik Lindgren, Tiago Moreira, Roberto Acampora, Alberto Negro, Theodoros Karapanayiotides, Shadi Yaghi, Anna Revert, Elisa Cuadrado Godia, Sebastian Garcia-Madrona, Paolino La Spina, Francesco GrilloFabrizio Giammello, Thanh N. Nguyen, Mohamad Abdalkader, Alina Buture, Maria Sofia Cotelli, Nicolas Raposo, Georgios Tsivgoulis, Paolo Candelaresi, Antonio Ciacciarelli, Joshua Mbroh, Tatiana Batenkova, Pasquale Scoppettuolo, Marialuisa Zedde, Rosario Pascarella, Kateryna Antonenko, Espen S. Kristoffersen, Johanna A. Kremer Hovinga, Katarina Jood, Diana Aguiar de Sousa, Sven Poli, Turgut Tatlisumak, Jukka Putaala, Jonathan M. Coutinho, José M. Ferro, Marcel Arnold, Mirjam R. Heldner

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Introduction: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. Patients and methods: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison. Outcome analyses were adjusted for age and sex. Results: We included 70 patients with COVID-CVT from 23 hospitals in 15 countries and 206 controls from 14 hospitals in 13 countries. The proportion of women was smaller in the COVID-CVT group (50% vs 68%, p < 0.01). A higher proportion of COVID-CVT patients presented with altered mental state (44% vs 25%, p < 0.01), the median thrombus load was higher in COVID-CVT patients (3 [IQR 2–4] vs 2 [1–3], p < 0.01) and the length of hospital stay was longer compared to controls (11 days [IQR 7–20] vs 8 [4–15], p = 0.02). In-hospital mortality did not differ (5/67 [7%, 95% CI 3–16] vs 7/206 [3%, 2–7], aOR 2.6 [95% CI 0.7–9]), nor did the frequency of functional independence after 6 months (modified Rankin Scale 0–2; 45/58 [78%, 95% CI 65–86] vs 161/185 [87%, 81–91], aOR 0.5 [95% CI 0.2–1.02]). Conclusion: In contrast to previous studies, the in-hospital mortality rate and functional outcomes during follow-up did not differ between COVID-CVT patients and the pre-COVID-19 controls.

Original languageEnglish
JournalEuropean Stroke Journal
Publication statusAccepted/In press - 2024


  • Cerebral venous thrombosis
  • COVID-19
  • stroke


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