TY - JOUR
T1 - Chediak-Higashi syndrome
AU - Siddiqui, Emad Uddin
AU - Hanif, Shaheena
N1 - Funding Information:
* From the Presbyterian Hospital, and the Departments of Medicine, Pathology and Biochemistry, College of Physicians and Surgeons, Columbia University, New York, New York. This investigation was supported in part by Research Grant (H-2907) from the National Heart Institute, U. S. Public Health Service, and a research grant from the American Heart Association and the Health Research Council, New York, New York. Manuscript received April 23, 1963. I Visiting Fellow, Department of Medicine, Trainee in Hematology, U. S. Public Health Service Grant (2A5321). Present address: SEATO Cholera Research Laboratory, Dacca, East Pakistan, India. $ Traveling Rockefeller Fellow, Department of Medicine 1961-62. Present address: Royal Free Hospital, London, England.
PY - 2008/4
Y1 - 2008/4
N2 - Chediak Higashi Syndrome is a rare inherited autosomal recessive disorder of immune system. Susceptibility to infection due to phagocyte dysfunction ranges from recurrent skin infection to over whelming fatal systemic infection. A five years old male child was admitted on 31st March 2006 with the complaints of pallor, fever & ear discharge for 6 month. He was treated by several medications but had temporary relief. The ear discharge was bilateral, foul smelling and of yellowish color. Past history was significant with episodes of abscess involving the different parts of body. Myeloid precursors shows giant, purple stained granules mainly in metamyelocytes, band cells and mature neutrophils.
AB - Chediak Higashi Syndrome is a rare inherited autosomal recessive disorder of immune system. Susceptibility to infection due to phagocyte dysfunction ranges from recurrent skin infection to over whelming fatal systemic infection. A five years old male child was admitted on 31st March 2006 with the complaints of pallor, fever & ear discharge for 6 month. He was treated by several medications but had temporary relief. The ear discharge was bilateral, foul smelling and of yellowish color. Past history was significant with episodes of abscess involving the different parts of body. Myeloid precursors shows giant, purple stained granules mainly in metamyelocytes, band cells and mature neutrophils.
KW - Chediak-Higashi syndrome
KW - Pediatric
KW - Recurrent skin abscess
UR - http://www.scopus.com/inward/record.url?scp=44849112801&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:44849112801
SN - 1682-024X
VL - 24
SP - 328
EP - 330
JO - Pakistan Journal of Medical Sciences
JF - Pakistan Journal of Medical Sciences
IS - 2
ER -