Chikungunya outbreak in Karachi Pakistan 2016-2017: An analysis of viral isolates

Dhani Prakoso, Kelli Barr, Kehkashan Imtiaz, Joveria Farooqi, Erum Khan, Maureen Long

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

In December 2016 physicians in Karachi, Pakistan,witnessed an increase in patients presenting with febrile illness and severe polyarthralgia. Subsequently, chikungunya virus (CHIKV)) was isolated from three patients. This virus was sequenced and compared with other isolates of CHIKV obtained in India and Pakistan during recent outbreaks. Phylogenetic analysis indicated that the Karachi isolates were most similar to the East Central South African CHIKV lineage and showed sequence homology to isolates obtained in other parts of Pakistan and India. More importantly, two of the CHIKV isolates had a nucleotide substitution in the E1 gene corresponding to an amino acid change at chain F portion of the E1 protein.

Original languageEnglish
Pages (from-to)1467-1471
Number of pages5
JournalJPMA. The Journal of the Pakistan Medical Association
Volume71
Issue number5
DOIs
Publication statusPublished - May 2021

Keywords

  • Arbovirus
  • Chikungunya virus
  • Karachi-Sindh
  • Nucleotide sequence
  • Pakistan

Fingerprint

Dive into the research topics of 'Chikungunya outbreak in Karachi Pakistan 2016-2017: An analysis of viral isolates'. Together they form a unique fingerprint.

Cite this