Chitosan capping of CuO nanoparticles: Facile chemical preparation, biological analysis, and applications in dentistry

Rabia Javed, Farwa Rais, Muhammad Kaleem, Bushra Jamil, Muhammad Arslan Ahmad, Tianhao Yu, Saba Waqar Qureshi, Qiang Ao

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

This investigation is vital contribution to the healthcare system utilizing techniques of nanobiotechnology. It interestingly applies chitosan capped CuO nanoparticles in the field of medicine and restorative dentistry. The CuO nanoparticles and CuO-Chitosan nanoparticles are prepared by co-precipitation, and their characterization is performed using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X-ray (EDX). The average crystallite size of these nanoparticles has been found to be in the dimensions of <40 nm and <35 nm, respectively. CuO-Chitosan nanoparticles show significant enhancement in in vitro antibacterial, antioxidant, cytotoxic, and antidiabetic activity as compared to CuO nanoparticles. In addition, the successful amalgamation of CuO nanoparticles and CuO-Chitosan nanoparticles into dentine bonding agents results in providing efficient remedy against secondary caries. CuO-Chitosan nanoparticles reinforced dental adhesive discs cause significant upsurge in reduction of Lactobacillus acidophillus and Streptococcus mutans. Also, the augmentation of mechanical properties, water sorption and solubility plus slow and sustained release profile and slight variation of shear bond strength is attained. Taken together, the chemically synthesized CuO nanoparticles and CuO-Chitosan nanoparticles have proven to be promising candidates having enormous potential to be utilized in drug delivery and nanotheranostics.

Original languageEnglish
Pages (from-to)1452-1467
Number of pages16
JournalInternational Journal of Biological Macromolecules
Volume167
DOIs
Publication statusPublished - 15 Jan 2021
Externally publishedYes

Keywords

  • Antibacterial activity
  • Antioxidant potential
  • Dental caries
  • Dentine bonding agents
  • Nanomedicine

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