Abstract
OBJECTIVE: To analyze the chromosomal abnormalities in couples with history of recurrent abortions. DESIGN: Retrospective study. SETTING: Cytogenetic section, Department of Pathology at the Aga Khan University Hospital, Karachi, Pakistan. PATIENTS: Three hundred couples with history of recurrent abortions. Main outcome measure: Structural chromosomal abnormalities in carrier couples. RESULTS: G-banded chromosomes were analyzed from both partners of 300 couples who had had two or more spontaneous abortions. Sixteen (5.3%) couples showed a chromosomal aberration in one of the partners. Seven translocations, 5 inversions, 2 deletions and 2 sex chromosomal abnormalities were identified. There was an increase in structural aberations, which was not significantly different from that reported worldwide. CONCLUSION: Chromosomal analysis is advocated as a primary tool in the evaluation of couples with repetitive fetal wastage.
| Original language | English |
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| Pages (from-to) | 117-119 |
| Number of pages | 3 |
| Journal | JPMA. The Journal of the Pakistan Medical Association |
| Volume | 53 |
| Issue number | 3 |
| Publication status | Published - Mar 2003 |