TY - JOUR
T1 - Clinical and bacteriologic efficacy of amoxycillin b.d. (45 mg/kg/day) Versus Amoxycillin t.d.s (40 mg/kg/day) in children with group A β-hemolytic streptococcal tonsillopharyngitis
AU - Aguilar, A.
AU - Tinoco, J. C.
AU - Macias, M.
AU - Huicho, L.
AU - Levy, J.
AU - Trujillo, H.
AU - Lopez, P.
AU - Pereira, M.
AU - Maqbool, S.
AU - Bhutta, Z. A.
AU - Sacy, R. A.
AU - Deacon, S.
PY - 2000
Y1 - 2000
N2 - This randomized, observer-blind, multicenter, parallel-group study compared the clinical and bacteriologic efficacy and safety of amoxycillin, 45 mg/kg/day b.d. and amoxycillin, 40 mg/kg/day t.d.s. after 7 days of treatment in 517 children with acute bacterial tonsillopharyngitis. At the end of treatment, a successful clinical response was recorded in more than 96% of patients in each of the treatment groups. A similar result was obtained at follow-up. Among those patients who were bacteriologically evaluable at the end of treatment, a successful bacteriologic response was achieved in more than 94% in each treatment group. Both treatments were well tolerated. Drug-related adverse events were recorded in just 12 patients (4.6%) in the b.d. group and six (2.4%) in the t.d.s. group. The study demonstrated that a twice-daily regimen of amoxycillin, 45 mg/kg/day, was as effective and as well tolerated as the standard three-times-daily regimen of amoxycillin, 40 mg/kg/day, in the treatment of acute bacterial tonsillopharyngitis in children.
AB - This randomized, observer-blind, multicenter, parallel-group study compared the clinical and bacteriologic efficacy and safety of amoxycillin, 45 mg/kg/day b.d. and amoxycillin, 40 mg/kg/day t.d.s. after 7 days of treatment in 517 children with acute bacterial tonsillopharyngitis. At the end of treatment, a successful clinical response was recorded in more than 96% of patients in each of the treatment groups. A similar result was obtained at follow-up. Among those patients who were bacteriologically evaluable at the end of treatment, a successful bacteriologic response was achieved in more than 94% in each treatment group. Both treatments were well tolerated. Drug-related adverse events were recorded in just 12 patients (4.6%) in the b.d. group and six (2.4%) in the t.d.s. group. The study demonstrated that a twice-daily regimen of amoxycillin, 45 mg/kg/day, was as effective and as well tolerated as the standard three-times-daily regimen of amoxycillin, 40 mg/kg/day, in the treatment of acute bacterial tonsillopharyngitis in children.
KW - Acute streptococcal tonsillopharyngitis
KW - Amoxycillin
KW - Group A streptococci
KW - Twice-daily formulation.
UR - http://www.scopus.com/inward/record.url?scp=0033766529&partnerID=8YFLogxK
U2 - 10.1179/joc.2000.12.5.396
DO - 10.1179/joc.2000.12.5.396
M3 - Article
C2 - 11128559
AN - SCOPUS:0033766529
SN - 1120-009X
VL - 12
SP - 396
EP - 405
JO - Journal of Chemotherapy
JF - Journal of Chemotherapy
IS - 5
ER -