Clinical and bacteriologic efficacy of amoxycillin b.d. (45 mg/kg/day) Versus Amoxycillin t.d.s (40 mg/kg/day) in children with group A β-hemolytic streptococcal tonsillopharyngitis

A. Aguilar, J. C. Tinoco, M. Macias, L. Huicho, J. Levy, H. Trujillo, P. Lopez, M. Pereira, S. Maqbool, Z. A. Bhutta, R. A. Sacy, S. Deacon

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5 Citations (Scopus)

Abstract

This randomized, observer-blind, multicenter, parallel-group study compared the clinical and bacteriologic efficacy and safety of amoxycillin, 45 mg/kg/day b.d. and amoxycillin, 40 mg/kg/day t.d.s. after 7 days of treatment in 517 children with acute bacterial tonsillopharyngitis. At the end of treatment, a successful clinical response was recorded in more than 96% of patients in each of the treatment groups. A similar result was obtained at follow-up. Among those patients who were bacteriologically evaluable at the end of treatment, a successful bacteriologic response was achieved in more than 94% in each treatment group. Both treatments were well tolerated. Drug-related adverse events were recorded in just 12 patients (4.6%) in the b.d. group and six (2.4%) in the t.d.s. group. The study demonstrated that a twice-daily regimen of amoxycillin, 45 mg/kg/day, was as effective and as well tolerated as the standard three-times-daily regimen of amoxycillin, 40 mg/kg/day, in the treatment of acute bacterial tonsillopharyngitis in children.

Original languageEnglish
Pages (from-to)396-405
Number of pages10
JournalJournal of Chemotherapy
Volume12
Issue number5
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Acute streptococcal tonsillopharyngitis
  • Amoxycillin
  • Group A streptococci
  • Twice-daily formulation.

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