TY - JOUR
T1 - Clinical characteristics and outcomes in patients with diabetes mellitus affected by COVID-19
T2 - a retrospective cross-sectional study from a tertiary care center in Pakistan
AU - Ahmed, Asma
AU - Ahmed, Salaar
AU - Malik, Manahil Tariq
AU - Zahid, Maheen
AU - Abdullah, Muhammad
AU - Ladak, Shamila
AU - Taufiq, Maliha
AU - Qureshi, Faiza
AU - Ali, Ayesha
AU - Golani, Shalni
AU - Jawed, Kinza
AU - Raja, Sajjan
AU - Chaipiwala, Maha
N1 - Publisher Copyright:
© The Author(s) 2025.
PY - 2025/12
Y1 - 2025/12
N2 - Background: COVID-19, caused by SARS-CoV-2, emerged in December 2019 and quickly became a global public health concern. Diabetes, a major risk factor for severe COVID-19, affects 537 million people worldwide, with high prevalence in low- and middle-income countries like Pakistan. Studies show diabetes increases the risk of severe COVID-19 complications and mortality. However, there is limited data on COVID-19 outcomes in diabetic patients in Pakistan. This study aims to fill this gap and examine factors affecting outcomes in this population. Methods: We conducted a retrospective cross-sectional study at The Aga Khan University Hospital, Karachi, encompassing 2,346 confirmed COVID-19 patients from February 26, 2020, to September 6, 2021. Data on diabetic status, following ADA guidelines and other clinical outcomes were collected from medical records and patient interviews. Statistical analysis was performed using SPSS V.25. Results: A total of 1,342 patients were included, with 864 males (64.4%) and 478 females (35.6%). The mean age was 56.59 ± 15.55 years. SARS-CoV-2 infection was the primary diagnosis for 741 patients (55.2%), while 601 patients (44.8%) had it as a secondary diagnosis. Of the total, 348 patients (25.9%) had T2DM, 2 patients (0.15%) had T1DM, and 991 patients (73.8%) were non-diabetic. The mean duration of diabetes was 2.01 ± 1.32 years. Diabetic patients had a significantly shorter mean hospital stay (4.99 ± 4.46 days) compared to non-diabetic patients (6.79 ± 7.32 days) (p < 0.001). The overall discharge rate was 70.3%, with a mortality rate of 10.7%. T2DM was associated with lower in-hospital mortality (p < 0.001) but higher rates of ARDS (p < 0.001). There was no significant association between T2DM and the risk of pulmonary aspergillosis, pulmonary embolism, or septic shock. Higher financial class was associated with longer hospital stays and a greater likelihood of being discharged home (p < 0.001). Conclusion: In conclusion, our study highlights the heightened susceptibility of COVID-19 patients with concurrent T1DM and T2DM to developing ARDS. Despite no significant association found between diabetes and adverse outcomes, the crucial role of tailored care for high-risk groups, particularly those with diabetes, cannot be overstated.
AB - Background: COVID-19, caused by SARS-CoV-2, emerged in December 2019 and quickly became a global public health concern. Diabetes, a major risk factor for severe COVID-19, affects 537 million people worldwide, with high prevalence in low- and middle-income countries like Pakistan. Studies show diabetes increases the risk of severe COVID-19 complications and mortality. However, there is limited data on COVID-19 outcomes in diabetic patients in Pakistan. This study aims to fill this gap and examine factors affecting outcomes in this population. Methods: We conducted a retrospective cross-sectional study at The Aga Khan University Hospital, Karachi, encompassing 2,346 confirmed COVID-19 patients from February 26, 2020, to September 6, 2021. Data on diabetic status, following ADA guidelines and other clinical outcomes were collected from medical records and patient interviews. Statistical analysis was performed using SPSS V.25. Results: A total of 1,342 patients were included, with 864 males (64.4%) and 478 females (35.6%). The mean age was 56.59 ± 15.55 years. SARS-CoV-2 infection was the primary diagnosis for 741 patients (55.2%), while 601 patients (44.8%) had it as a secondary diagnosis. Of the total, 348 patients (25.9%) had T2DM, 2 patients (0.15%) had T1DM, and 991 patients (73.8%) were non-diabetic. The mean duration of diabetes was 2.01 ± 1.32 years. Diabetic patients had a significantly shorter mean hospital stay (4.99 ± 4.46 days) compared to non-diabetic patients (6.79 ± 7.32 days) (p < 0.001). The overall discharge rate was 70.3%, with a mortality rate of 10.7%. T2DM was associated with lower in-hospital mortality (p < 0.001) but higher rates of ARDS (p < 0.001). There was no significant association between T2DM and the risk of pulmonary aspergillosis, pulmonary embolism, or septic shock. Higher financial class was associated with longer hospital stays and a greater likelihood of being discharged home (p < 0.001). Conclusion: In conclusion, our study highlights the heightened susceptibility of COVID-19 patients with concurrent T1DM and T2DM to developing ARDS. Despite no significant association found between diabetes and adverse outcomes, the crucial role of tailored care for high-risk groups, particularly those with diabetes, cannot be overstated.
KW - Acute respiratory distress syndrome (ARDS)
KW - COVID-19
KW - Diabetes mellitus
KW - In-Hospital mortality
KW - Pakistan healthcare
KW - SARS-CoV-2
UR - https://www.scopus.com/pages/publications/105007524944
U2 - 10.1186/s12902-025-01908-1
DO - 10.1186/s12902-025-01908-1
M3 - Article
AN - SCOPUS:105007524944
SN - 1472-6823
VL - 25
JO - BMC Endocrine Disorders
JF - BMC Endocrine Disorders
IS - 1
M1 - 143
ER -
