Background: Esophageal cancer is the eighth most prevalent cancer globally. Previously, several biomarkers have been used to predict the prognosis, although with variable reliability. Interestingly, it is noted that changes in liver function tests levels before and after neoadjuvant treatment are predictive in terms of cancer recurrence. Objectives: The objectives of the current study were to associate novel markers, including aspartate aminotransferase-to-platelet ratio (APRI) and aspartate aminotransferase-to-alanine aminotransferase ratio (AAR) with survival in esophageal malignancy. Materials and Methods: A retrospective study in a tertiary care hospital (single-center) included 951 patients having diagnosed esophageal carcinoma of any age group. Results: The median (interquartile range) age of study participants were 50 (38-60) years, including 43% males and 57% female patients, while the median (interquartile range) levels of AAR and APRI were 0.97 (0.81-1.25) and 0.19 (0.13-0.29), respectively. AAR was found to be higher in dysphagia for solids only and dysphagia for both liquids and solids rather than liquids only (P = 0.002), while other associations included well-differentiated tumor grade (P = 0.011), finding of esophageal stricture on esophagogastroduodenoscopy (P = 0.015), and characteristic of mass on computerized tomography scan being both circumferential and mural (P = 0.005). APRI was found to be higher in adenocarcinoma (P = 0.038), and finding of circumferential ± ulcerated mass on esophagogastroduodenoscopy (P < 0.001). On survival analysis, adenocarcinoma (P < 0.001), luminal narrowing (P = 0.002), AAR greater than 1.0 (P = 0.006), and APRI greater than 0.2 (P = 0.007) were found to be poor survival predictors. On Cox proportional hazards regression, APRI was found to be more associated with poor survival than AAR (Hazard ratio: 1.682, 1.208-2.340, P = 0.002). Conclusion: This study correlated clinical and pathological features of esophageal malignancy with noninvasive markers of hepatic function.