Clinicopathological features and surgical outcomes of resected functional pancreatic neuroendocrine tumors: A single institution experience

Ammar A. Javed, Alina Hasanain, Aleezay Haider, George Jones, Zunaira N. Javed, Kevin Soares, Richard A. Burkhart, John L. Cameron, Matthew J. Weiss, Christopher L. Wolfgang, Jin He

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Background:Functional pancreatic neuroendocrine tumors (f-PanNETs) are rare tumors of the pancreas that are associated with excess hormone production. A majority of literature available on these tumors is limited to case reports and small series and discusses a particular subtype. Here, we report the clinicopathological features and outcomes of all f-PanNETs from a high-volume pancreatectomy center.Methods:A prospectively maintained database was used to identify patients who underwent resection for f-PanNETs between January 1995 and December 2015. Patients were stratified by the type of f-PanNET, and their clinicopathological features and outcomes were analyzed and reported.Results:We identified 69 patients with a mean age of 52 ± 16 years, and the majority were female (62%). The most common type of f-PanNET were insulinomas (70%) followed by gastrinomas (15%), and vasoactive intestinal peptidomas (VIPomas) (10%). There was considerable heterogeneity in the presenting symptoms. Patients with insulinomas presented with smaller tumors compared to the other subtypes. Nodal disease was most frequent in patients with VIPomas (71%), and gastrinomas (50%). The median overall survival (OS) was 7.4 years. Elevated Ki-67 and age >65 years were associated with poorer OS. Recurrence was observed in 8 patients (12%) and was most frequent in patients with VIPomas. Recurrence was associated with a poorer OS (P = .012).Conclusion:f-PanNETs are exceedingly rare and present with a wide variety of symptoms, histopathological findings, and outcomes. Surgical resection can help achieve good long-term survival.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalJournal of Pancreatology
Issue number2
Publication statusPublished - Jun 2019
Externally publishedYes


  • Functional tumor
  • Outcome
  • Pancreatic neuroendocrine tumor


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