Clinicopathological prognostic factors of oral squamous cell carcinoma: An experience of a tertiary care hospital

Sayed Akbar Abbas, Javeria Saeed, Muhammad Usman Tariq, Ahmed Raheem Baksh, Salman Hashmi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Locoregional recurrence accounts for majority of the treatment failures in oral cancer patients. Current study aimed to determine the predictors of recurrence and survival in patients with biopsy proven Squamous Cell Carcinoma (SCC) of the oral cavity. This study included 88 patients of squamous cell carcinoma treated at our institution from 2007 till 2013. Primary intervention was surgery in all patients with radiation and chemotherapy in selected patients. Primary end point was locoregional recurrence, distant metastasis and death. Out of 88 patients, 23 (26.1%) patients developed locoregional recurrence and 6 (6.8%) patients developed distant metastasis. Overall survival rate was 77.3%. Follow up ranged from 1 month to 63 months with mean of 17.8±16.2. On multivariate analysis, lymph node involvement and loco-regional recurrence were independent parameters related to decrease overall survival. Lymphovascular invasion, perineural spread, TNM stage and lymph node involvement had significant impact on recurrence.

Original languageEnglish
Pages (from-to)1115-1119
Number of pages5
JournalJournal of the Pakistan Medical Association
Volume68
Issue number7
Publication statusPublished - Jul 2018
Externally publishedYes

Keywords

  • Metastasis
  • Oral cavity
  • Radiotherapy
  • Recurrence
  • Squamous cell carcinoma

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