Comparative studies of S-bridged complexes of 99mTc with fac(S)-[M(aet)3] (M = RhIII, IrIII; Aet = 2-aminoethanethiolate)

N. Amir; S. Roohi; A. Mushtaq; S. Pervez; S. Saeed

doi:10.1524/ract.2009.1642

Comparative studies of S-bridged complexes of ^99mTc with fac(S)-[M(aet)₃] (M = Rh^III, Ir^III; Aet = 2-aminoethanethiolate)

N. Amir, S. Roohi, A. Mushtaq, S. Pervez, S. Saeed

Research output: Contribution to journal › Article › peer-review

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Abstract

fac(S)-[Ir(aet)₃] (aet = 2-aminoethanethiolate) is N3S3 metalloligand, which forms S-bridged polynuclear complexes with transition metal ions. A complex analogous to [Re{Ir(aet₃)}₂]³⁺ was formed by the reaction of ^99mTcO₄Na and fac(S)-[Ir(aet)₃] in the presence of SnCl₂2H₂O. A simple method for radiollabelling of fac(S)-[Ir(aet)₃] with ^9mTo was developed with radiolabelling efficiency higher than 99%. Effects of SnCl₂-2H₂O concentration, time and pH on the radiolabelling efficiency were determined and compared with ^99mTc- [Rh(aet)₃]. ^99mTc-[Ir(aet)₃] was also characterized by electrophoresis, HPLC, biodistribution studies in rats and scintigraphy in rabbit. Higher uptake by kidneys showed rapid distribution of the labelled fac(S)-[Ir(aet)₃]. Scintigrams show that liver, bladder and skeletal uptake were significant. The results of biodistribution showed that ^99mTc-[Ir(aet)₃] uptake is quite rapid as compared to ^99mTc-[Rh(aet)₃].

Original language	English
Pages (from-to)	507-512
Number of pages	6
Journal	Radiochimica Acta
Volume	97
Issue number	9
DOIs	https://doi.org/10.1524/ract.2009.1642
Publication status	Published - 2009
Externally published	Yes

Keywords

2-aminoethanethiolate
Labelling
Metalloligands
S-bridged complexes
Scintigraphy

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@article{33a52b516c4140e3a71506318f461f4f,

title = "Comparative studies of S-bridged complexes of 99mTc with fac(S)-[M(aet)3] (M = RhIII, IrIII; Aet = 2-aminoethanethiolate)",

abstract = "fac(S)-[Ir(aet)3] (aet = 2-aminoethanethiolate) is N3S3 metalloligand, which forms S-bridged polynuclear complexes with transition metal ions. A complex analogous to [Re{Ir(aet3)}2]3+ was formed by the reaction of 99mTcO4Na and fac(S)-[Ir(aet)3] in the presence of SnCl22H2O. A simple method for radiollabelling of fac(S)-[Ir(aet)3] with 9mTo was developed with radiolabelling efficiency higher than 99%. Effects of SnCl2-2H2O concentration, time and pH on the radiolabelling efficiency were determined and compared with 99mTc- [Rh(aet)3]. 99mTc-[Ir(aet)3] was also characterized by electrophoresis, HPLC, biodistribution studies in rats and scintigraphy in rabbit. Higher uptake by kidneys showed rapid distribution of the labelled fac(S)-[Ir(aet)3]. Scintigrams show that liver, bladder and skeletal uptake were significant. The results of biodistribution showed that 99mTc-[Ir(aet)3] uptake is quite rapid as compared to 99mTc-[Rh(aet)3].",

keywords = "2-aminoethanethiolate, Labelling, Metalloligands, S-bridged complexes, Scintigraphy",

author = "N. Amir and S. Roohi and A. Mushtaq and S. Pervez and S. Saeed",

year = "2009",

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T1 - Comparative studies of S-bridged complexes of 99mTc with fac(S)-[M(aet)3] (M = RhIII, IrIII; Aet = 2-aminoethanethiolate)

AU - Amir, N.

AU - Roohi, S.

AU - Mushtaq, A.

AU - Pervez, S.

AU - Saeed, S.

PY - 2009

Y1 - 2009

N2 - fac(S)-[Ir(aet)3] (aet = 2-aminoethanethiolate) is N3S3 metalloligand, which forms S-bridged polynuclear complexes with transition metal ions. A complex analogous to [Re{Ir(aet3)}2]3+ was formed by the reaction of 99mTcO4Na and fac(S)-[Ir(aet)3] in the presence of SnCl22H2O. A simple method for radiollabelling of fac(S)-[Ir(aet)3] with 9mTo was developed with radiolabelling efficiency higher than 99%. Effects of SnCl2-2H2O concentration, time and pH on the radiolabelling efficiency were determined and compared with 99mTc- [Rh(aet)3]. 99mTc-[Ir(aet)3] was also characterized by electrophoresis, HPLC, biodistribution studies in rats and scintigraphy in rabbit. Higher uptake by kidneys showed rapid distribution of the labelled fac(S)-[Ir(aet)3]. Scintigrams show that liver, bladder and skeletal uptake were significant. The results of biodistribution showed that 99mTc-[Ir(aet)3] uptake is quite rapid as compared to 99mTc-[Rh(aet)3].

AB - fac(S)-[Ir(aet)3] (aet = 2-aminoethanethiolate) is N3S3 metalloligand, which forms S-bridged polynuclear complexes with transition metal ions. A complex analogous to [Re{Ir(aet3)}2]3+ was formed by the reaction of 99mTcO4Na and fac(S)-[Ir(aet)3] in the presence of SnCl22H2O. A simple method for radiollabelling of fac(S)-[Ir(aet)3] with 9mTo was developed with radiolabelling efficiency higher than 99%. Effects of SnCl2-2H2O concentration, time and pH on the radiolabelling efficiency were determined and compared with 99mTc- [Rh(aet)3]. 99mTc-[Ir(aet)3] was also characterized by electrophoresis, HPLC, biodistribution studies in rats and scintigraphy in rabbit. Higher uptake by kidneys showed rapid distribution of the labelled fac(S)-[Ir(aet)3]. Scintigrams show that liver, bladder and skeletal uptake were significant. The results of biodistribution showed that 99mTc-[Ir(aet)3] uptake is quite rapid as compared to 99mTc-[Rh(aet)3].

KW - 2-aminoethanethiolate

KW - Labelling

KW - Metalloligands

KW - S-bridged complexes

KW - Scintigraphy

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DO - 10.1524/ract.2009.1642

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JO - Radiochimica Acta

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Comparative studies of S-bridged complexes of ^99mTc with fac(S)-[M(aet)₃] (M = Rh^III, Ir^III; Aet = 2-aminoethanethiolate)

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