Comparative studies of S-bridged complexes of 99mTc with fac(S)-[M(aet)3] (M = RhIII, IrIII; Aet = 2-aminoethanethiolate)

N. Amir, S. Roohi, A. Mushtaq, S. Pervez, S. Saeed

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1 Citation (Scopus)


fac(S)-[Ir(aet)3] (aet = 2-aminoethanethiolate) is N3S3 metalloligand, which forms S-bridged polynuclear complexes with transition metal ions. A complex analogous to [Re{Ir(aet3)}2]3+ was formed by the reaction of 99mTcO4Na and fac(S)-[Ir(aet)3] in the presence of SnCl22H2O. A simple method for radiollabelling of fac(S)-[Ir(aet)3] with 9mTo was developed with radiolabelling efficiency higher than 99%. Effects of SnCl2-2H2O concentration, time and pH on the radiolabelling efficiency were determined and compared with 99mTc- [Rh(aet)3]. 99mTc-[Ir(aet)3] was also characterized by electrophoresis, HPLC, biodistribution studies in rats and scintigraphy in rabbit. Higher uptake by kidneys showed rapid distribution of the labelled fac(S)-[Ir(aet)3]. Scintigrams show that liver, bladder and skeletal uptake were significant. The results of biodistribution showed that 99mTc-[Ir(aet)3] uptake is quite rapid as compared to 99mTc-[Rh(aet)3].

Original languageEnglish
Pages (from-to)507-512
Number of pages6
JournalRadiochimica Acta
Issue number9
Publication statusPublished - 2009
Externally publishedYes


  • 2-aminoethanethiolate
  • Labelling
  • Metalloligands
  • S-bridged complexes
  • Scintigraphy


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