TY - JOUR
T1 - Comparison of serum levels of vitamin d and vitamin d-binding protein in normal, osteopenic and osteoporotic postmenopausal women
AU - Murad, Rafat
AU - Mahboob, Tabassum
AU - Rehman, Rehana
AU - Baig, Rozeena
N1 - Funding Information:
study was supported by a grant from Higher Education Commission (No.5215/Sindh/NRPU/ R&D/HEC/2016) and is in accordance to the policy of the funding organization on research objectivity. We are extremely thankful to the Department of Biochemistry BMSI, JPMC Karachi and especially Dr. Rafat Murad for approaching (pre and postmenopausal females), inviting them to come for enrollment in the study, providing them slots for DEXA scan and facilitating their work up at AKU. Our special thanks to Dr. Aisha Sheikh, Consultant Endocrinologist at Aga Khan University Hospital.
Funding Information:
Grant Support and Financial Disclosures: Thestudy was supported by a grant from Higher Education Commission (No.5215/Sindh/NRPU/ R&D/HEC/2016) and is in accordance to the policy of the funding organization on research objectivity. We are extremely thankful to the Department of Biochemistry BMSI, JPMC Karachi and especially Dr. Rafat Murad for approaching (pre and postmenopausal females), inviting them to come for enrollment in the study, providing them slots for DEXA scan and facilitating their work up at AKU.Our special thanks to Dr. Aisha Sheikh, Consultant Endocrinologist at Aga Khan University Hospital.
Publisher Copyright:
© 2019, Professional Medical Publications. All rights reserved.
PY - 2019/2/26
Y1 - 2019/2/26
N2 - Objective: To compare the serum levels of vitamin D, vitamin D binding protein (VDBP) calcium and phosphate in normal, osteopenic and osteoporotic postmenopausal women categorized on the basis of bone mineral density (BMD) scores. Methods: A cross sectional study carried out from May 2017 to August 2018. BMD measured by Dual energy X-ray Absorptiometry categorized women (aged 20-70 years) into normal (n=37) (T score ≥-1.0) osteopenic (n=25) (-2.5< T score, <-1) and osteoporotic (n= 26) (T score <-2.5) according to WHO classification. Serum concentrations of vitamin D, VDBP, calcium, phosphate analyzed by enzyme linked immunosorbent assay were compared by Analysis of Variance Results: In normal females higher levels of vitamin D and VDBP were observed [15.82 (8-69.18), 469.9 (269.57-875.55)] vs. osteopenic [(7.45 (4.66-15.1), 296.05 (232.58-420.23)] and osteoporotic women [(7.25 (3.97-17.49), 272.94 (202.23-351.24)]; [median interquartile range]; p value < 0.0001. Conclusion: Vitamin D and VDBP are linked with bone health and estimation of VDBP appears to be a valuable tool for the assessment of increased bone loss and possible risks of bone fractures especially in postmenopausal women.
AB - Objective: To compare the serum levels of vitamin D, vitamin D binding protein (VDBP) calcium and phosphate in normal, osteopenic and osteoporotic postmenopausal women categorized on the basis of bone mineral density (BMD) scores. Methods: A cross sectional study carried out from May 2017 to August 2018. BMD measured by Dual energy X-ray Absorptiometry categorized women (aged 20-70 years) into normal (n=37) (T score ≥-1.0) osteopenic (n=25) (-2.5< T score, <-1) and osteoporotic (n= 26) (T score <-2.5) according to WHO classification. Serum concentrations of vitamin D, VDBP, calcium, phosphate analyzed by enzyme linked immunosorbent assay were compared by Analysis of Variance Results: In normal females higher levels of vitamin D and VDBP were observed [15.82 (8-69.18), 469.9 (269.57-875.55)] vs. osteopenic [(7.45 (4.66-15.1), 296.05 (232.58-420.23)] and osteoporotic women [(7.25 (3.97-17.49), 272.94 (202.23-351.24)]; [median interquartile range]; p value < 0.0001. Conclusion: Vitamin D and VDBP are linked with bone health and estimation of VDBP appears to be a valuable tool for the assessment of increased bone loss and possible risks of bone fractures especially in postmenopausal women.
KW - Bone mineral density
KW - Post menopausal females
KW - Vitamin D
KW - Vitamin D-binding protein
UR - http://www.scopus.com/inward/record.url?scp=85067405908&partnerID=8YFLogxK
U2 - 10.12669/pjms.35.2.714
DO - 10.12669/pjms.35.2.714
M3 - Article
AN - SCOPUS:85067405908
SN - 1682-024X
VL - 35
SP - 543
EP - 548
JO - Pakistan Journal of Medical Sciences
JF - Pakistan Journal of Medical Sciences
IS - 2
ER -