TY - JOUR
T1 - Consensus guidelines for the management of adult low-grade gliomas for low and middle-income countries
AU - Pakistan Brain Tumour Consortium
AU - Khan, Ahsan Ali
AU - Waheed, Ayesha Akbar
AU - Ahmed, Ali Azan
AU - Hafiz, Asim
AU - Zaki, Adeeba
AU - Gilani, Ahmed
AU - Urooj, Faiza
AU - Bajwa, Mohammad Hamza
AU - Enam, Syed Ather
PY - 2024/3/1
Y1 - 2024/3/1
N2 - Low-grade gliomas (LGG) are brain tumors of glial cells origin. They are grade 1 and grade 2 tumors according to the WHO classification. Diagnosis of LGG is made through imaging, histopathological analysis, and use of molecular markers. Imaging alone does not establish the grade of the tumor and thus a histopathological examination of tissue is crucial in establishing the definite histopathological diagnosis. Clinical presentation varies according to the location and size of the tumor. Surgical resection is strongly recommended in LGG over observation to improve overall survival as surgery leads to greater benefit due to progression-free survival. Radiation has shown benefits in LGG patients in randomized controlled trials and chemotherapy with temozolomide has also shown good results. This paper covers the principles of low-grade gliomas management and summarizes the recommendations for the LMICs.
AB - Low-grade gliomas (LGG) are brain tumors of glial cells origin. They are grade 1 and grade 2 tumors according to the WHO classification. Diagnosis of LGG is made through imaging, histopathological analysis, and use of molecular markers. Imaging alone does not establish the grade of the tumor and thus a histopathological examination of tissue is crucial in establishing the definite histopathological diagnosis. Clinical presentation varies according to the location and size of the tumor. Surgical resection is strongly recommended in LGG over observation to improve overall survival as surgery leads to greater benefit due to progression-free survival. Radiation has shown benefits in LGG patients in randomized controlled trials and chemotherapy with temozolomide has also shown good results. This paper covers the principles of low-grade gliomas management and summarizes the recommendations for the LMICs.
KW - Temozolomide, survival, brain Neoplasms, glioma, neuroglia
UR - http://www.scopus.com/inward/record.url?scp=85204089340&partnerID=8YFLogxK
U2 - 10.47391/JPMA.S3.GNO-11
DO - 10.47391/JPMA.S3.GNO-11
M3 - Article
C2 - 39262069
AN - SCOPUS:85204089340
SN - 0030-9982
VL - 74
SP - S93-S99
JO - JPMA. The Journal of the Pakistan Medical Association
JF - JPMA. The Journal of the Pakistan Medical Association
IS - 3 3
ER -