Contaminant Metals and Cardiovascular Health

Karl Kristian Lundin, Yusuf Kamran Qadeer, Zhen Wang, Salim Virani, Roman Leischik, Carl J. Lavie, Markus Strauss, Chayakrit Krittanawong

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


A growing body of research has begun to link exposure to environmental contaminants, such as heavy metals, with a variety of negative health outcomes. In this paper, we sought to review the current research describing the impact of certain common contaminant metals on cardiovascular (CV) health. We reviewed ten metals: lead, barium, nickel, chromium, cadmium, arsenic, mercury, selenium, zinc, and copper. After a literature review, we briefly summarized the routes of environmental exposure, pathophysiological mechanisms, CV health impacts, and exposure prevention and/or mitigation strategies for each metal. The resulting article discloses a broad spectrum of pathological significance, from relatively benign substances with little to no described effects on CV health, such as chromium and selenium, to substances with a wide-ranging and relatively severe spectrum of CV pathologies, such as arsenic, cadmium, and lead. It is our hope that this article will provide clinicians with a practical overview of the impact of these common environmental contaminants on CV health as well as highlight areas that require further investigation to better understand how these metals impact the incidence and progression of CV diseases.

Original languageEnglish
Article number450
JournalJournal of Cardiovascular Development and Disease
Issue number11
Publication statusPublished - Nov 2023


  • cardiac toxicity
  • cardiac toxins
  • cardiology and environmental science
  • cardiology and metal toxins
  • cardiology and metals
  • cardiovascular disease
  • cardiovascular metal toxicity
  • cardiovascular toxicity
  • environmental cardiac toxins
  • environmental contaminants and cardiovascular toxicity
  • environmental heart toxins
  • heart and metal toxicity
  • heart toxicity
  • heart toxins
  • metal toxicity
  • metals and cardiovascular disease


Dive into the research topics of 'Contaminant Metals and Cardiovascular Health'. Together they form a unique fingerprint.

Cite this