TY - JOUR
T1 - Core outcome sets for prevention and treatment of postpartum haemorrhage
T2 - an international Delphi consensus study
AU - Meher, S.
AU - Cuthbert, A.
AU - Kirkham, J. J.
AU - Williamson, P.
AU - Abalos, E.
AU - Aflaifel, N.
AU - Bhutta, Z. A.
AU - Bishop, A.
AU - Blum, J.
AU - Collins, P.
AU - Devane, D.
AU - Ducloy-Bouthors, A. S.
AU - Fawole, B.
AU - Gülmezoglu, A. M.
AU - Gutteridge, K.
AU - Gyte, G.
AU - Homer, C. S.E.
AU - Mallaiah, S.
AU - Smith, J. M.
AU - Weeks, A. D.
AU - Alfirevic, Z.
N1 - Publisher Copyright:
© 2018 Royal College of Obstetricians and Gynaecologists
PY - 2019/1
Y1 - 2019/1
N2 - Objective: To develop core outcome sets (COS) for studies evaluating interventions for (1) prevention and (2) treatment of postpartum haemorrhage (PPH), and recommendations on how to report the COS. Design: A two-round Delphi survey and face-to-face meeting. Population: Healthcare professionals and women's representatives. Methods: Outcomes were identified from systematic reviews of PPH studies and stakeholder consultation. Participants scored each outcome in the Delphi on a Likert scale between 1 (not important) and 9 (critically important). Results were discussed at the face-to-face meeting to agree the final COS. Consensus at the meeting was defined as ≥ 70% of participants scoring the outcome as critically important (7–9). Lectures, discussion and voting were used to agree how to report COS outcomes. Main outcome measures: Outcomes from systematic reviews and consultations. Results: Both Delphi rounds were completed by 152/205 (74%) participants for prevention and 143/197 (73%) for treatment. For prevention of PPH, nine core outcomes were selected: blood loss, shock, maternal death, use of additional uterotonics, blood transfusion, transfer for higher level of care, women's sense of wellbeing, acceptability and satisfaction with the intervention, breastfeeding, and adverse effects. For treatment of PPH, 12 core outcomes were selected: blood loss, shock, coagulopathy, hysterectomy, organ dysfunction, maternal death, blood transfusion, use of additional haemostatic intervention, transfer for higher level of care, women's sense of wellbeing, acceptability and satisfaction with the intervention, breastfeeding, and adverse effects. Recommendations were developed on how to report these outcomes where possible. Conclusions: These COS will help standardise outcome reporting in PPH trials. Tweetable abstract: Core outcome sets for PPH: nine core outcomes for PPH prevention and 12 core outcomes for PPH treatment.
AB - Objective: To develop core outcome sets (COS) for studies evaluating interventions for (1) prevention and (2) treatment of postpartum haemorrhage (PPH), and recommendations on how to report the COS. Design: A two-round Delphi survey and face-to-face meeting. Population: Healthcare professionals and women's representatives. Methods: Outcomes were identified from systematic reviews of PPH studies and stakeholder consultation. Participants scored each outcome in the Delphi on a Likert scale between 1 (not important) and 9 (critically important). Results were discussed at the face-to-face meeting to agree the final COS. Consensus at the meeting was defined as ≥ 70% of participants scoring the outcome as critically important (7–9). Lectures, discussion and voting were used to agree how to report COS outcomes. Main outcome measures: Outcomes from systematic reviews and consultations. Results: Both Delphi rounds were completed by 152/205 (74%) participants for prevention and 143/197 (73%) for treatment. For prevention of PPH, nine core outcomes were selected: blood loss, shock, maternal death, use of additional uterotonics, blood transfusion, transfer for higher level of care, women's sense of wellbeing, acceptability and satisfaction with the intervention, breastfeeding, and adverse effects. For treatment of PPH, 12 core outcomes were selected: blood loss, shock, coagulopathy, hysterectomy, organ dysfunction, maternal death, blood transfusion, use of additional haemostatic intervention, transfer for higher level of care, women's sense of wellbeing, acceptability and satisfaction with the intervention, breastfeeding, and adverse effects. Recommendations were developed on how to report these outcomes where possible. Conclusions: These COS will help standardise outcome reporting in PPH trials. Tweetable abstract: Core outcome sets for PPH: nine core outcomes for PPH prevention and 12 core outcomes for PPH treatment.
KW - Core outcomes
KW - Delphi
KW - postpartum haemorrhage
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=85051129306&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.15335
DO - 10.1111/1471-0528.15335
M3 - Article
C2 - 29920912
AN - SCOPUS:85051129306
SN - 1470-0328
VL - 126
SP - 83
EP - 93
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 1
ER -