TY - JOUR
T1 - Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men
AU - Chirinos, Julio A.
AU - Zambrano, Juan P.
AU - Virani, Salim S.
AU - Jimenez, Joaquin J.
AU - Jy, Wenche
AU - Ahn, Eugene
AU - Horstman, Lawrence L.
AU - Castellanos, Agustin
AU - Myerburg, Robert J.
AU - Ahn, Yeon S.
N1 - Funding Information:
This study was supported by the Wallace H. Coulter Foundation, Miami, Florida, funds from Mary Beth Weiss and Jane and Charles Bosco, and gifts from Frank Smather, Miami, Florida.
PY - 2005/5/15
Y1 - 2005/5/15
N2 - Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.
AB - Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.
UR - http://www.scopus.com/inward/record.url?scp=20944448356&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2005.01.063
DO - 10.1016/j.amjcard.2005.01.063
M3 - Article
C2 - 15878008
AN - SCOPUS:20944448356
SN - 0002-9149
VL - 95
SP - 1258
EP - 1260
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 10
ER -