Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men

Julio A. Chirinos; Juan P. Zambrano; Salim S. Virani; Joaquin J. Jimenez; Wenche Jy; Eugene Ahn; Lawrence L. Horstman; Agustin Castellanos; Robert J. Myerburg; Yeon S. Ahn

doi:10.1016/j.amjcard.2005.01.063

Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men

Julio A. Chirinos
, Juan P. Zambrano
, Salim S. Virani
, Joaquin J. Jimenez
, Wenche Jy
, Eugene Ahn
, Lawrence L. Horstman
, Agustin Castellanos
, Robert J. Myerburg
, Yeon S. Ahn

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.

Original language	English (US)
Pages (from-to)	1258-1260
Number of pages	3
Journal	American Journal of Cardiology
Volume	95
Issue number	10
DOIs	https://doi.org/10.1016/j.amjcard.2005.01.063
Publication status	Published - 15 May 2005
Externally published	Yes

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10.1016/j.amjcard.2005.01.063

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Chirinos, J. A., Zambrano, J. P., Virani, S. S., Jimenez, J. J., Jy, W., Ahn, E., Horstman, L. L., Castellanos, A., Myerburg, R. J., & Ahn, Y. S. (2005). Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men. American Journal of Cardiology, 95(10), 1258-1260. https://doi.org/10.1016/j.amjcard.2005.01.063

@article{6a0cb575e1a94546849d58f5abb20d6d,

title = "Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men",

abstract = "Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.",

author = "Chirinos, \{Julio A.\} and Zambrano, \{Juan P.\} and Virani, \{Salim S.\} and Jimenez, \{Joaquin J.\} and Wenche Jy and Eugene Ahn and Horstman, \{Lawrence L.\} and Agustin Castellanos and Myerburg, \{Robert J.\} and Ahn, \{Yeon S.\}",

note = "Funding Information: This study was supported by the Wallace H. Coulter Foundation, Miami, Florida, funds from Mary Beth Weiss and Jane and Charles Bosco, and gifts from Frank Smather, Miami, Florida. ",

year = "2005",

month = may,

day = "15",

doi = "10.1016/j.amjcard.2005.01.063",

language = "English (US)",

volume = "95",

pages = "1258--1260",

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TY - JOUR

T1 - Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men

AU - Chirinos, Julio A.

AU - Zambrano, Juan P.

AU - Virani, Salim S.

AU - Jimenez, Joaquin J.

AU - Jy, Wenche

AU - Ahn, Eugene

AU - Horstman, Lawrence L.

AU - Castellanos, Agustin

AU - Myerburg, Robert J.

AU - Ahn, Yeon S.

N1 - Funding Information: This study was supported by the Wallace H. Coulter Foundation, Miami, Florida, funds from Mary Beth Weiss and Jane and Charles Bosco, and gifts from Frank Smather, Miami, Florida.

PY - 2005/5/15

Y1 - 2005/5/15

N2 - Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.

AB - Inflammation has been associated with increased cardiovascular risk, and endothelial cell (EC) apoptosis has been implicated in atherogenesis. The correlation between circulating concentrations of interleukin-6 (IL-6), C-reactive protein (CRP), and endothelial microparticles (EMPs) expressing an apoptotic (EMP31) or activation (EMP62E) phenotype in 20 middle-aged healthy men was investigated. IL-6 was significantly correlated with EMP31 (r = 0.6, p = 0.004), which persisted after adjusting for body mass index and CRP. CRP was significantly correlated with body mass index (r = 0.49, p = 0.02) but not with EMP31 or EMP62E. EC apoptosis is associated with IL-6 levels in men and might be partially responsible for the increased cardiovascular risk associated with subclinical inflammation.

UR - https://www.scopus.com/pages/publications/20944448356

U2 - 10.1016/j.amjcard.2005.01.063

DO - 10.1016/j.amjcard.2005.01.063

M3 - Article

C2 - 15878008

AN - SCOPUS:20944448356

SN - 0002-9149

VL - 95

SP - 1258

EP - 1260

JO - American Journal of Cardiology

JF - American Journal of Cardiology

IS - 10

ER -

Correlation between apoptotic endothelial microparticles and serum interleukin-6 and C-reactive protein in healthy men

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