Cortical gray-white matter blurring and cognitive morbidity in focal cortical dysplasia

Karen Blackmon, Ruben Kuzniecky, William B. Barr, Matija Snuderl, Werner Doyle, Orrin Devinsky, Thomas Thesen

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Focal cortical dysplasia (FCD) is a malformation of cortical development that is associated with high rates of cognitive morbidity. However, the degree to which specific irregularities of dysplastic tissue directly impact cognition remains unknown. This study investigates the relationship between blurring of the cortical gray and white matter boundary on magnetic resonance imaging (MRI) and global cognitive abilities in FCD. Gray-white blurring (GWB) is quantified by sampling the non-normalized T1 image intensity contrast above and below the gray and white matter interface along the cortical mantle. Spherical averaging is used to compare resulting GWB for patients with histopathologically verified FCD with matched controls. Whole-brain correlational analyses are used to investigate the relationship between blurring and general cognitive abilities, controlling for epilepsy duration. Results show that cognitive performance is reduced in patients with FCD relative to controls. Patients show increased GWB in bilateral temporal, parietal, and frontal regions. Furthermore, increased GWB in these regions is linearly related to decreased cognition and mediates group differences in cognitive performance. These findings demonstrate that GWB is a marker of reduced cognitive efficiency in FCD that can potentially be used to probe general and domain-specific cognitive functions in other neurological disorders.

Original languageEnglish
Pages (from-to)2854-2862
Number of pages9
JournalCerebral Cortex
Issue number9
Publication statusPublished - 1 Sept 2015
Externally publishedYes


  • Cognition
  • Epilepsy
  • Focal cortical dysplasia
  • Gray and white matter blurring
  • Quantitative MRI


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