Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy

Tracy Butler; Karen Blackmon; Carrie R. McDonald; Chad Carlson; William B. Barr; Orrin Devinsky; Ruben Kuzniecky; Jonathan DuBois; Jacqueline French; Eric Halgren; Thomas Thesen

doi:10.1016/j.yebeh.2011.10.001

Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy

Tracy Butler, Karen Blackmon, Carrie R. McDonald, Chad Carlson, William B. Barr, Orrin Devinsky, Ruben Kuzniecky, Jonathan DuBois, Jacqueline French, Eric Halgren, Thomas Thesen

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Depression in patients with temporal lobe epilepsy (TLE) is highly prevalent and carries significant morbidity and mortality. Its neural basis is poorly understood. We used quantitative, surface-based MRI analysis to correlate brain morphometry with severity of depressive symptoms in 38 patients with TLE and 45 controls. Increasing severity of depressive symptoms was associated with orbitofrontal cortex (OFC) thinning in controls, but with OFC thickening in TLE patients. These results demonstrate distinct neuroanatomical substrates for depression with and without TLE, and suggest a unique role for OFC, a limbic region for emotional processing strongly interconnected with medial temporal structures, in TLE-related depressive symptoms.

Original language	English
Pages (from-to)	64-67
Number of pages	4
Journal	Epilepsy and Behavior
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.yebeh.2011.10.001
Publication status	Published - Jan 2012
Externally published	Yes

Keywords

Beck Depression Inventory
Cortical thickness
Depression
Epilepsy
Freesurfer
Magnetic resonance imaging
Mood
Morphometry
Orbitofrontal cortex
Temporal lobe epilepsy

Access to Document

10.1016/j.yebeh.2011.10.001

Cite this

@article{8fb78c74540049809f6ccede367d9000,

title = "Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy",

abstract = "Depression in patients with temporal lobe epilepsy (TLE) is highly prevalent and carries significant morbidity and mortality. Its neural basis is poorly understood. We used quantitative, surface-based MRI analysis to correlate brain morphometry with severity of depressive symptoms in 38 patients with TLE and 45 controls. Increasing severity of depressive symptoms was associated with orbitofrontal cortex (OFC) thinning in controls, but with OFC thickening in TLE patients. These results demonstrate distinct neuroanatomical substrates for depression with and without TLE, and suggest a unique role for OFC, a limbic region for emotional processing strongly interconnected with medial temporal structures, in TLE-related depressive symptoms.",

keywords = "Beck Depression Inventory, Cortical thickness, Depression, Epilepsy, Freesurfer, Magnetic resonance imaging, Mood, Morphometry, Orbitofrontal cortex, Temporal lobe epilepsy",

author = "Tracy Butler and Karen Blackmon and McDonald, {Carrie R.} and Chad Carlson and Barr, {William B.} and Orrin Devinsky and Ruben Kuzniecky and Jonathan DuBois and Jacqueline French and Eric Halgren and Thomas Thesen",

year = "2012",

month = jan,

doi = "10.1016/j.yebeh.2011.10.001",

language = "English",

volume = "23",

pages = "64--67",

journal = "Epilepsy and Behavior",

issn = "1525-5050",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy

AU - Butler, Tracy

AU - Blackmon, Karen

AU - McDonald, Carrie R.

AU - Carlson, Chad

AU - Barr, William B.

AU - Devinsky, Orrin

AU - Kuzniecky, Ruben

AU - DuBois, Jonathan

AU - French, Jacqueline

AU - Halgren, Eric

AU - Thesen, Thomas

PY - 2012/1

Y1 - 2012/1

N2 - Depression in patients with temporal lobe epilepsy (TLE) is highly prevalent and carries significant morbidity and mortality. Its neural basis is poorly understood. We used quantitative, surface-based MRI analysis to correlate brain morphometry with severity of depressive symptoms in 38 patients with TLE and 45 controls. Increasing severity of depressive symptoms was associated with orbitofrontal cortex (OFC) thinning in controls, but with OFC thickening in TLE patients. These results demonstrate distinct neuroanatomical substrates for depression with and without TLE, and suggest a unique role for OFC, a limbic region for emotional processing strongly interconnected with medial temporal structures, in TLE-related depressive symptoms.

AB - Depression in patients with temporal lobe epilepsy (TLE) is highly prevalent and carries significant morbidity and mortality. Its neural basis is poorly understood. We used quantitative, surface-based MRI analysis to correlate brain morphometry with severity of depressive symptoms in 38 patients with TLE and 45 controls. Increasing severity of depressive symptoms was associated with orbitofrontal cortex (OFC) thinning in controls, but with OFC thickening in TLE patients. These results demonstrate distinct neuroanatomical substrates for depression with and without TLE, and suggest a unique role for OFC, a limbic region for emotional processing strongly interconnected with medial temporal structures, in TLE-related depressive symptoms.

KW - Beck Depression Inventory

KW - Cortical thickness

KW - Depression

KW - Epilepsy

KW - Freesurfer

KW - Magnetic resonance imaging

KW - Mood

KW - Morphometry

KW - Orbitofrontal cortex

KW - Temporal lobe epilepsy

UR - http://www.scopus.com/inward/record.url?scp=84855907183&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2011.10.001

DO - 10.1016/j.yebeh.2011.10.001

M3 - Article

C2 - 22099527

AN - SCOPUS:84855907183

SN - 1525-5050

VL - 23

SP - 64

EP - 67

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

IS - 1

ER -

Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this