Craniocerebral aspergillosis: A review of advances in diagnosis and management

Muhammad Shahzad Shamim, Syed Ather Enam, Rushna Ali, Saleha Anwar

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


Craniocerebral aspergillosis is a rare but dangerous central nervous system infection. The infection has a spectrum of presenting features, mostly affecting immunocompromised individuals. The incidence appears to be on the rise that has been especially observed in the immunocompetent population. A high index of suspicion, a comprehensive understanding of the infectious process and advanced laboratory and radiological diagnostic techniques, allow early diagnosis. Surgery, followed by systemic antifungal medications, remains the cornerstone of management. Early administration of empirical anti-fungal agents along with immunomodulators may further improve prognosis. Immunocompetent patients tend to have better outcomes as compared to those who are immunocompromised. Patients with intradural disease carry the worst prognosis.

Original languageEnglish
Pages (from-to)573-579
Number of pages7
JournalJournal of the Pakistan Medical Association
Issue number7
Publication statusPublished - Jul 2010


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