Dengue-induced Guillain–Barre syndrome: a case series

Hina Imtiaz, Ayisha Farooq Khan, Sara Khan

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Dengue virus is an RNA virus that is associated with a myriad of neurological manifestations. Less than 5% of patients develop neuromuscular complications. Guillain–Barre syndrome (GBS) is an uncommon neurological sequelae of dengue fever. Studies have shown acute motor axonal neuropathy (AMAN) and acute motor sensory axonal neuropathy (AMSAN) to be the most common variants associated with dengue fever in Asian countries. Very few cases have been reported from Pakistan to date. Case presentation: We present four adult patients with dengue-associated GBS. The time interval between onset of symptoms of dengue fever and development of lower limb weakness in all patients was between 6 and 20 days. Dengue was diagnosed based on either serology or dengue NS1 antigen testing. Acute inflammatory demyelinating polyneuropathy (AIDP) (n = 1), AMAN (n = 1), and AMSAN (n = 2) variants were identified. One patient had a coexisting myopathy which has not been previously reported. All patients showed good recovery after treatment with plasmapheresis or intravenous immunoglobulins. Conclusions: Our case series is valuable in contributing to the limited pool of reported cases of dengue fever complicated by GBS. Early detection of new onset symmetrical limb weakness during or after a dengue infection is imperative for early treatment and to limit disability.

Original languageEnglish
Article number149
JournalEgyptian Journal of Neurology, Psychiatry and Neurosurgery
Volume59
Issue number1
DOIs
Publication statusPublished - Dec 2023

Keywords

  • Acute inflammatory demyelinating polyneuropathy
  • Dengue virus
  • Guillain–Barre syndrome
  • Intravenous immunoglobulin
  • Plasmapheresis

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