TY - JOUR
T1 - Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings
AU - Haque, Md Ahshanul
AU - Platts-Mills, James A.
AU - Mduma, Estomih
AU - Bodhidatta, Ladaporn
AU - Bessong, Pascal
AU - Shakoor, Sadia
AU - Kang, Gagandeep
AU - Kosek, Margaret N.
AU - Lima, Aldo A.M.
AU - Shrestha, Sanjaya K.
AU - Alam, Md Ashraful
AU - Havt, Alexandre
AU - Samie, Amidou
AU - Guerrant, Richard L.
AU - Lang, Dennis
AU - Mahfuz, Mustafa
AU - Bhutta, Zulfiqar A.
AU - Houpt, Eric R.
AU - Ahmed, Tahmeed
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of this study was to assess the association between both all Campylobacter species infections and Campylobacter jejuni/coli infections on growth and enteric inflammation in children aged 1–24 months. We analyzed data from 1715 children followed from birth until 24 months of age in the MAL-ED birth cohort study, including detection of Campylobacter species by enzyme immunoassay and Campylobacter jejuni/coli by quantitative PCR in stool samples. Myeloperoxidase (MPO) concentration in stool, used as a quantitative index of enteric inflammation, was measured. The incidence rate per 100 child-months of infections with Campylobacter jejuni/coli and Campylobacter species during 1–24 month follow up were 17.7 and 29.6 respectively. Female sex of child, shorter duration of exclusive breastfeeding, lower maternal age, mother having less than 3 living children, maternal educational level of <6 years, lack of routine treatment of drinking water, and unimproved sanitation were associated with Campylobacter jejuni/coli infection. The cumulative burden of both Campylobacter jejuni/coli infections and Campylobacter species were associated with poor growth and increased intestinal inflammation.
AB - Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of this study was to assess the association between both all Campylobacter species infections and Campylobacter jejuni/coli infections on growth and enteric inflammation in children aged 1–24 months. We analyzed data from 1715 children followed from birth until 24 months of age in the MAL-ED birth cohort study, including detection of Campylobacter species by enzyme immunoassay and Campylobacter jejuni/coli by quantitative PCR in stool samples. Myeloperoxidase (MPO) concentration in stool, used as a quantitative index of enteric inflammation, was measured. The incidence rate per 100 child-months of infections with Campylobacter jejuni/coli and Campylobacter species during 1–24 month follow up were 17.7 and 29.6 respectively. Female sex of child, shorter duration of exclusive breastfeeding, lower maternal age, mother having less than 3 living children, maternal educational level of <6 years, lack of routine treatment of drinking water, and unimproved sanitation were associated with Campylobacter jejuni/coli infection. The cumulative burden of both Campylobacter jejuni/coli infections and Campylobacter species were associated with poor growth and increased intestinal inflammation.
UR - http://www.scopus.com/inward/record.url?scp=85075434485&partnerID=8YFLogxK
U2 - 10.1038/s41598-019-53533-3
DO - 10.1038/s41598-019-53533-3
M3 - Article
C2 - 31748573
AN - SCOPUS:85075434485
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 17124
ER -
