TY - JOUR
T1 - Determinants of Campylobacter infection and association with growth and enteric inflammation in children under 2 years of age in low-resource settings
AU - Haque, Md Ahshanul
AU - Platts-Mills, James A.
AU - Mduma, Estomih
AU - Bodhidatta, Ladaporn
AU - Bessong, Pascal
AU - Shakoor, Sadia
AU - Kang, Gagandeep
AU - Kosek, Margaret N.
AU - Lima, Aldo A.M.
AU - Shrestha, Sanjaya K.
AU - Alam, Md Ashraful
AU - Havt, Alexandre
AU - Samie, Amidou
AU - Guerrant, Richard L.
AU - Lang, Dennis
AU - Mahfuz, Mustafa
AU - Bhutta, Zulfiqar A.
AU - Houpt, Eric R.
AU - Ahmed, Tahmeed
N1 - Funding Information:
We thank the staff and participants of the MAL-ED Network for their important contributions. We acknowledge with gratitude the commitment of the Government of the People’s Republic of Bangladesh to icddr,b’s research strength. We also acknowledge the following donors for providing unrestricted support to icddr,b’s effort and advancement to its strategic plan: Canada (DFATD), Sweden (SIDA), and the United Kingdom (DFID). The study was funded by University of Virginia with support from MAL-ED Network Investigators in the Foundation of National Institute of Health, Fogarty International Centre (FIC) with overall support from the Bill & Melinda Gates Foundation. We also acknowledge all the research assistants who conducted the interviews during data collection.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of this study was to assess the association between both all Campylobacter species infections and Campylobacter jejuni/coli infections on growth and enteric inflammation in children aged 1–24 months. We analyzed data from 1715 children followed from birth until 24 months of age in the MAL-ED birth cohort study, including detection of Campylobacter species by enzyme immunoassay and Campylobacter jejuni/coli by quantitative PCR in stool samples. Myeloperoxidase (MPO) concentration in stool, used as a quantitative index of enteric inflammation, was measured. The incidence rate per 100 child-months of infections with Campylobacter jejuni/coli and Campylobacter species during 1–24 month follow up were 17.7 and 29.6 respectively. Female sex of child, shorter duration of exclusive breastfeeding, lower maternal age, mother having less than 3 living children, maternal educational level of <6 years, lack of routine treatment of drinking water, and unimproved sanitation were associated with Campylobacter jejuni/coli infection. The cumulative burden of both Campylobacter jejuni/coli infections and Campylobacter species were associated with poor growth and increased intestinal inflammation.
AB - Campylobacter species infections have been associated with malnutrition and intestinal inflammation among children in low-resource settings. However, it remains unclear whether that association is specific to Campylobacter jejuni/coli. The aim of this study was to assess the association between both all Campylobacter species infections and Campylobacter jejuni/coli infections on growth and enteric inflammation in children aged 1–24 months. We analyzed data from 1715 children followed from birth until 24 months of age in the MAL-ED birth cohort study, including detection of Campylobacter species by enzyme immunoassay and Campylobacter jejuni/coli by quantitative PCR in stool samples. Myeloperoxidase (MPO) concentration in stool, used as a quantitative index of enteric inflammation, was measured. The incidence rate per 100 child-months of infections with Campylobacter jejuni/coli and Campylobacter species during 1–24 month follow up were 17.7 and 29.6 respectively. Female sex of child, shorter duration of exclusive breastfeeding, lower maternal age, mother having less than 3 living children, maternal educational level of <6 years, lack of routine treatment of drinking water, and unimproved sanitation were associated with Campylobacter jejuni/coli infection. The cumulative burden of both Campylobacter jejuni/coli infections and Campylobacter species were associated with poor growth and increased intestinal inflammation.
UR - http://www.scopus.com/inward/record.url?scp=85075434485&partnerID=8YFLogxK
U2 - 10.1038/s41598-019-53533-3
DO - 10.1038/s41598-019-53533-3
M3 - Article
C2 - 31748573
AN - SCOPUS:85075434485
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 17124
ER -
