TY - JOUR
T1 - Determinants of metabolic syndrome and its prognostic implications among stroke patients in Africa
T2 - Findings from the Stroke Investigative Research and Educational Network (SIREN) study
AU - SIREN
AU - Adeoye, Abiodun M.
AU - Akintunde, Adeseye A.
AU - Akinyemi, Joshua
AU - Fakunle, Adekunle G.
AU - Sarfo, Fred S.
AU - Akpalu, Albert
AU - Wahab, Kolawole
AU - Obiako, Reginald
AU - Komolafe, Morenikeji
AU - Owolabi, Lukman
AU - Osaigbovo, Godwin O.
AU - Akpa, Onoja
AU - Arulogun, Oyedunni
AU - Okekunle, Akinkunmi P.
AU - Ogah, Okechukwu S.
AU - Jenkins, Carolyn
AU - Ogbole, Godwin
AU - Tiwari, Hemant K.
AU - Asowata, Osahon J.
AU - Ibinaiye, Philip
AU - Appiah, Lambert
AU - Agunloye, Atinuke M.
AU - Yaria, Joseph
AU - Calys-Tagoe, Benedict
AU - Agbogu-Ike, Obiageli U.
AU - Adeniyi, Sunday
AU - Adebayo, Philip
AU - Balogun, Olayemi
AU - Aderonmu, Olajumoke
AU - Adeegbe, Oluwayemisi T.
AU - Adebayo, Oladimeji
AU - Akinyemi, Rufus
AU - Ovbiagele, Bruce
AU - Owolabi, Mayowa
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/10/15
Y1 - 2022/10/15
N2 - Background: The prognostic implications of metabolic syndrome (METS) among African stroke patients are poorly understood. This study aimed to investigate the determinants of METS and its prognostic implications among Africans with newly diagnosed stroke in the SIREN study. Methods: We included stroke cases (adults aged >18 years with CT/MRI confirmed stroke). The validated tools comprehensively evaluated vascular, lifestyle, and psychosocial factors. We used logistic regression to estimate adjusted odds ratios (OR) with 95% CIs for the association between METS and risk factors. We also computed the prediction power of the domain of covariates in a sequential manner using the area under the receiver operating curve (ROC) curve. Results: Among 3998 stroke subjects enrolled in the study, 76.8% had METS by at least one of the clinical definitions. Factors associated with METS were age > 50 years (OR- 1.46, CI-1.19-1.80), male gender (OR 4.06, CI- 3.28-5.03), income >100USD (OR1.42, CI-1.17-1.71), stress (OR1.46, CI-1.14-1.87), family history of diabetes mellitus (OR1.38, CI-1.06-1.78), and cardiac disease (OR1.42, CI-1.18-1.65). Stroke severity was higher among those with METS (SLS = 5.8 ± 4.3) compared with those without METS (6.2 ± 4.5) at p = 0.037. METS was associated with higher odds (aOR 1.31, CI-1.08-1.58) of one-month fatality after adjusting for stroke severity, age > 50 years, and average monthly income >100USD. Conclusion: METS is very common among African stroke patients and is associated with stroke severity and worse one-month fatality. Lifestyle interventions may prevent METS and attenuate its impact on stroke occurrence and outcomes.
AB - Background: The prognostic implications of metabolic syndrome (METS) among African stroke patients are poorly understood. This study aimed to investigate the determinants of METS and its prognostic implications among Africans with newly diagnosed stroke in the SIREN study. Methods: We included stroke cases (adults aged >18 years with CT/MRI confirmed stroke). The validated tools comprehensively evaluated vascular, lifestyle, and psychosocial factors. We used logistic regression to estimate adjusted odds ratios (OR) with 95% CIs for the association between METS and risk factors. We also computed the prediction power of the domain of covariates in a sequential manner using the area under the receiver operating curve (ROC) curve. Results: Among 3998 stroke subjects enrolled in the study, 76.8% had METS by at least one of the clinical definitions. Factors associated with METS were age > 50 years (OR- 1.46, CI-1.19-1.80), male gender (OR 4.06, CI- 3.28-5.03), income >100USD (OR1.42, CI-1.17-1.71), stress (OR1.46, CI-1.14-1.87), family history of diabetes mellitus (OR1.38, CI-1.06-1.78), and cardiac disease (OR1.42, CI-1.18-1.65). Stroke severity was higher among those with METS (SLS = 5.8 ± 4.3) compared with those without METS (6.2 ± 4.5) at p = 0.037. METS was associated with higher odds (aOR 1.31, CI-1.08-1.58) of one-month fatality after adjusting for stroke severity, age > 50 years, and average monthly income >100USD. Conclusion: METS is very common among African stroke patients and is associated with stroke severity and worse one-month fatality. Lifestyle interventions may prevent METS and attenuate its impact on stroke occurrence and outcomes.
KW - Africans
KW - Metabolic syndrome
KW - Prognostic implications
KW - Stroke
KW - Stroke Investigative Research and Educational Network (SIREN)
UR - http://www.scopus.com/inward/record.url?scp=85135883194&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2022.120360
DO - 10.1016/j.jns.2022.120360
M3 - Article
C2 - 35985161
AN - SCOPUS:85135883194
SN - 0022-510X
VL - 441
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
M1 - 120360
ER -