Abstract
The purpose of present study was to develop chemically cross-linked chitosan-co-poly(AMPS) hydrogel for pH-responsive and controlled delivery of valsartan. Hydrogels were synthesized using the free radical polymerization technique. A polymer (high molecular weight chitosan) was chemically cross-linked with monomer (2-acrylamido-2-methylpropane sulfonic acid (AMPS)) in aqueous medium. NʹNʹ-Methylenebisacrylamide was used as a cross-linker. Sodium hydrogen sulfite and ammonium peroxodisulfate were used as initiators. Drug loading was performed with valsartan as a model drug. Characterization of hydrogels was performed by SEM, FTIR, and DSC. Hydrogels were evaluated for pH-responsive behavior by the equilibrium swelling ratio and swelling dynamics at low and high pH. The developed cross-linked network showed pH-dependent drug release characteristics. Maximum swelling, drug loading, and release have been observed at pH 7.4. It is concluded that highly stable chitosan and AMPS-based polymeric matrices are developed. These polymeric matrices have potential to be used as a carrier for controlled delivery of valsartan.
| Original language | English (UK) |
|---|---|
| Pages (from-to) | 361-368 |
| Number of pages | 8 |
| Journal | Advances in Polymer Technology |
| Volume | 35 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Dec 2016 |
| Externally published | Yes |
Keywords
- Chitosan
- Drug Delivery Systems
- Hydrogel
- pH responsive
- Swelling
- Valsartan