TY - JOUR
T1 - Diagnostic and prognostic role of cancer stem cell biomarkers in oral squamous cell carcinoma; A Systematic Review
AU - Ali, Faiza
AU - Siddiqui, Tania Arshad
AU - Sukhia, Rashna Hoshang
AU - Maqsood, Ayesha
AU - Ghandhi, Dinaz
N1 - Publisher Copyright:
© 2023 Pakistan Medical Association. All rights reserved.
PY - 2023/2
Y1 - 2023/2
N2 - Objective: To evaluate the role of cancer stem cell biomarkers in diagnosis and prognosis of OSCC patients. Methods: The search strategy was entered into PubMed NLM, EBSCO CINAHL, EBSCO Dentistry & Oral Sciences Source, Wiley Cochrane Library, and Scopus. The full text eligible studies (n=7) were assessed for their quality using the JBI Critical Appraisal Checklist to evaluates the methodological quality of the studies based on possibility of bias in its design, conduct, and analysis. Selected studies were further analysed based on different parameters such as publication year, sample size, and outcomes. Results: A total of 432 studies were identified through the search strategy. A total of 306 records were removed before screening either because of duplication or marked ineligible by the automation tools. The screened records were 126 out of which 104 were removed as they were not conducted on OSCC. Twenty-two reports were sought for retrieval, however, we could not find the full text of 3 studies and12 studies were excluded because the biomarkers were not associated with cancer stem cells. The most common cancer stem cell biomarkers associated with OSCC were MCT1,VEGF-A, GD15, HIF1 α, Ki67, Hsp 70, Cyclin D1, and CD44. Conclusions: Various stem cell biomarkers have been found to have diagnostic and prognostic role in oral squamous cell carcinoma such as Cyclin D1, VEGF-A, GD15, and CD44. They can be used to predict the overall survival rate, local progression-free survival rate, and distant metastasis-free survival rate in Head and Neck cancer patients.
AB - Objective: To evaluate the role of cancer stem cell biomarkers in diagnosis and prognosis of OSCC patients. Methods: The search strategy was entered into PubMed NLM, EBSCO CINAHL, EBSCO Dentistry & Oral Sciences Source, Wiley Cochrane Library, and Scopus. The full text eligible studies (n=7) were assessed for their quality using the JBI Critical Appraisal Checklist to evaluates the methodological quality of the studies based on possibility of bias in its design, conduct, and analysis. Selected studies were further analysed based on different parameters such as publication year, sample size, and outcomes. Results: A total of 432 studies were identified through the search strategy. A total of 306 records were removed before screening either because of duplication or marked ineligible by the automation tools. The screened records were 126 out of which 104 were removed as they were not conducted on OSCC. Twenty-two reports were sought for retrieval, however, we could not find the full text of 3 studies and12 studies were excluded because the biomarkers were not associated with cancer stem cells. The most common cancer stem cell biomarkers associated with OSCC were MCT1,VEGF-A, GD15, HIF1 α, Ki67, Hsp 70, Cyclin D1, and CD44. Conclusions: Various stem cell biomarkers have been found to have diagnostic and prognostic role in oral squamous cell carcinoma such as Cyclin D1, VEGF-A, GD15, and CD44. They can be used to predict the overall survival rate, local progression-free survival rate, and distant metastasis-free survival rate in Head and Neck cancer patients.
KW - Carcinoma
KW - Dentistry
KW - Head and Neck
KW - Ki-67 Antigen
KW - Larynx
KW - Nasopharynx
KW - Neoplasms
KW - Neoplastic
KW - Prognosis
KW - Squamous Cell
KW - Stem Cells
UR - http://www.scopus.com/inward/record.url?scp=85147510478&partnerID=8YFLogxK
U2 - 10.47391/JPMA.AKUS-06
DO - 10.47391/JPMA.AKUS-06
M3 - Review article
AN - SCOPUS:85147510478
SN - 0030-9982
VL - 73
SP - S32-S39
JO - Journal of the Pakistan Medical Association
JF - Journal of the Pakistan Medical Association
IS - 2
ER -
