TY - JOUR
T1 - Differential associations between body composition indices and neurodevelopment during early life in term-born infants
T2 - findings from the Pakistan cohort: Multi-Center Body Composition Reference Study
AU - Ariff, Shabina
AU - Aamir, Almas
AU - Young, Aneurin
AU - Sikanderali, Laila
AU - Rizvi, Arjumand
AU - Shaheen, Fariha
AU - Khan, Gul Nawaz
AU - Soofi, Sajid
AU - Fernandes, Michelle
N1 - Funding Information:
This study was funded by International Atomic Energy Agency, Vienna, Austria (SA, IAEA Doctoral Contract No: 18124/R2). The funding body had no role in the design, analysis or writing of this article.
Funding Information:
We are grateful to the families and participants who have contributed to the study. This study was funded by the International Atomic Energy Agency, Vienna, Austria. The authors are grateful to Alexia J. Alford, Nutrition Specialist at the IAEA, for facilitating the analysis of body composition. MF is supported by a Clinical Research Training Fellowship from the Medical Research Council, UK.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Objective: We examined associations between fat free mass (FFM) and fat mass (FM) accretion during the first 1000 days of life and neurodevelopment in term-born, low-risk infants from Karachi, Pakistan. Design: Prospective, observational study nested within the larger Multi-Center Body Composition Reference Study. FFM, FM, and fat% were estimated using measured deuterium dilution method. Neurodevelopmental outcomes were assessed at 24 months on the INTER-NDA (INTERGROWTH-21st Project Neurodevelopment Assessment) (n = 132). Results: Children with gross motor delays had significantly lower FFM at 18 months (8.01 ± 0.97 kg vs. 7.55 ± 0.20 kg). Children with positive and negative behavior problems had significantly higher fat% at 24 months (20.62 ± 4.30% vs. 18.23 ± 5.46%) and 20.89 ± 4.24% vs. 18.54 ± 5.38%). No associations remained significant after adjusting for covariates. Trajectory modeling showed that between 12 and 18 months, negative behavior scores changed by 13.8 points for every standard deviation change in fat accretion. Conclusions: Our findings highlight the importance of balancing neurodevelopment and metabolic risk when designing nutritional interventions for young children.
AB - Objective: We examined associations between fat free mass (FFM) and fat mass (FM) accretion during the first 1000 days of life and neurodevelopment in term-born, low-risk infants from Karachi, Pakistan. Design: Prospective, observational study nested within the larger Multi-Center Body Composition Reference Study. FFM, FM, and fat% were estimated using measured deuterium dilution method. Neurodevelopmental outcomes were assessed at 24 months on the INTER-NDA (INTERGROWTH-21st Project Neurodevelopment Assessment) (n = 132). Results: Children with gross motor delays had significantly lower FFM at 18 months (8.01 ± 0.97 kg vs. 7.55 ± 0.20 kg). Children with positive and negative behavior problems had significantly higher fat% at 24 months (20.62 ± 4.30% vs. 18.23 ± 5.46%) and 20.89 ± 4.24% vs. 18.54 ± 5.38%). No associations remained significant after adjusting for covariates. Trajectory modeling showed that between 12 and 18 months, negative behavior scores changed by 13.8 points for every standard deviation change in fat accretion. Conclusions: Our findings highlight the importance of balancing neurodevelopment and metabolic risk when designing nutritional interventions for young children.
UR - http://www.scopus.com/inward/record.url?scp=85164526424&partnerID=8YFLogxK
U2 - 10.1038/s41430-023-01296-6
DO - 10.1038/s41430-023-01296-6
M3 - Article
AN - SCOPUS:85164526424
SN - 0954-3007
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
ER -