Differential Lipid Response to Statins Is Associated with Variants in the BUD13-APOA5 Gene Region

Sarah E. O'Brien, Steven J. Schrodi, Zhan Ye, Murray H. Brilliant, Salim S. Virani, Ariel Brautbar

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Genetic variants within the BUD13-APOA5 gene region are known to be associated with high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels. Recent studies suggest that single nucleotide polymorphisms (SNPs) within this region affect HDL-C response to statin-fibrate combination therapy and lowdensity lipoprotein cholesterol (LDL-C) response to statin therapy. We hypothesized that SNPs within the BUD13-APOA5 region are associated with TG, HDL-C, and LDL-C response to statin therapy. We examined 1520 observations for 1086 patients from the Personalized Medicine Research Project, a large biorepository at the Marshfield Clinic Research Foundation, who had received statin therapy and been previously genotyped for polymorphisms in the 11q23 chromosomal region. A significant differential response to statin therapy was observed for 3 SNPs. The minor allele at rs11605293 significantly attenuated TG-lowering response to pravastatin (P = 0.000159), whereas the minor allele at rs12806755 was associated with a similar response to lovastatin (P = 0.000192). Genotypes at rs947990 significantly attenuated LDL-C reduction to atorvastatin therapy (P = 0.000668) with some patients with the minor allele having LDL-C increase after therapy. No SNPs within the BUD13-APOA5 region were associated with a significant effect on HDL-C reduction in response to statin therapy. In conclusion, this study suggests that common SNPs within the BUD13-APOA5 can affect TG and LDL-C response to statin therapy in a North American population.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalJournal of Cardiovascular Pharmacology
Volume66
Issue number2
DOIs
Publication statusPublished - 21 Aug 2015
Externally publishedYes

Keywords

  • HDL-C
  • LDL-C
  • Pharmacogenetics
  • genetic association
  • statin response
  • triglycerides

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